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Anim Cells Syst (Seoul)

Title:		The microRNA-127-3p directly targeting Vamp2 in C2C12 myoblasts
Author(s):		Li J; Wang G; Jiang J; Fu L; Zhou P; Ren H;
Address:		"Herbivorous Livestock Institute, Chongqing Academy of Animal Sciences, Chongqing, People's Republic of China"
Journal Title:		Anim Cells Syst (Seoul)
Year:		2018
Volume:		20180825
Issue:		5
Page Number:		299 - 304
DOI:		10.1080/19768354.2018.1512520
ISSN/ISBN:		1976-8354 (Print) 2151-2485 (Electronic) 1976-8354 (Linking)
Abstract:		"MicroRNAs (miRNAs) have been reported that can regulate skeletal muscle growth and development. Previously, we demonstrated that miR-127-3p were differently expressed in skeletal muscle and muscle cells. However, the molecular mechanism of miR-127-3p regulation of skeletal myogenesis are not well elucidated. In this study, we transfected miR-127-3p into C2C12 cells, and found miR-127-3p induces myogenesis by targeting Vamp2. Moreover, the regulatory mechanism of Vamp2 in myoblasts proliferation and differentiation was further confirmed. In conclusion, our data providedevidences that miR-127-3p reciprocally regulated myoblasts proliferation and differentiation through directly targeting Vamp2"
Keywords:		C2c12 Myogenesis Vamp2 miR-127-3p;
Notes:		"PubMed-not-MEDLINELi, Jie Wang, Gaofu Jiang, Jing Fu, Lin Zhou, Peng Ren, Hangxing eng England 2018/11/22 Anim Cells Syst (Seoul). 2018 Aug 25; 22(5):299-304. doi: 10.1080/19768354.2018.1512520. eCollection 2018"