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Clin J Am Soc Nephrol

Title:		Environment-Wide Association Study of CKD
Author(s):		Lee J; Oh S; Kang H; Kim S; Lee G; Li L; Kim CT; An JN; Oh YK; Lim CS; Kim DK; Kim YS; Choi K; Lee JP;
Address:		"Department of Internal Medicine, Seoul National University Boramae Medical Center, Seoul, Republic of Korea. Medical Research Collaborating Center, Seoul National University Boramae Medical Center, Seoul, Republic of Korea. Department of Environmental Health Sciences, School of Public Health, Seoul National University, Seoul, Republic of Korea. Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea. Institute of Life and Death Studies, Hallym University, Chuncheon, Republic of Korea. Department of Internal Medicine, Hallym University Sacred Heart Hospital, Anyang, Republic of Korea. Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea"
Journal Title:		Clin J Am Soc Nephrol
Year:		2020
Volume:		20200522
Issue:		6
Page Number:		766 - 775
DOI:		10.2215/CJN.06780619
ISSN/ISBN:		1555-905X (Electronic) 1555-9041 (Print) 1555-9041 (Linking)
Abstract:		"BACKGROUND AND OBJECTIVES: Exposure to environmental chemicals has been recognized as one of the possible contributors to CKD. We aimed to identify environmental chemicals that are associated with CKD. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We analyzed the data obtained from a total of 46,748 adults who participated in the National Health and Nutrition Examination Survey (1999-2016). Associations of chemicals measured in urine or blood (n=262) with albuminuria (urine albumin-to-creatinine ratio >/=30 mg/g), reduced eGFR (<60 ml/min per 1.73 m(2)), and a composite of albuminuria or reduced eGFR were tested and validated using the environment-wide association study approach. RESULTS: Among 262 environmental chemicals, seven (3%) chemicals showed significant associations with increased risk of albuminuria, reduced eGFR, or the composite outcome. These chemicals included metals and other chemicals that have not previously been associated with CKD. Serum and urine cotinines, blood 2,5-dimethylfuran (a volatile organic compound), and blood cadmium were associated with albuminuria. Blood lead and cadmium were associated with reduced eGFR. Blood cadmium and lead and three volatile compounds (blood 2,5-dimethylfuran, blood furan, and urinary phenylglyoxylic acid) were associated with the composite outcome. A total of 23 chemicals, including serum perfluorooctanoic acid, seven urinary metals, three urinary arsenics, urinary nitrate and thiocyanate, three urinary polycyclic aromatic hydrocarbons, and seven volatile organic compounds, were associated with lower risks of one or more manifestations of CKD. CONCLUSIONS: A number of chemicals were identified as potential risk factors for CKD among the general population"
Keywords:		"Adolescent Adult Aged Aged, 80 and over Albuminuria/*epidemiology Arsenicals/urine Cadmium/blood Cotinine/blood/urine Environmental Exposure/*statistics & numerical data Female Furans/blood *Glomerular Filtration Rate Glyoxylates/urine Humans Lead/blood M;"
Notes:		"MedlineLee, Jeonghwan Oh, Sohee Kang, Habyeong Kim, Sunmi Lee, Gowoon Li, Lilin Kim, Clara Tammy An, Jung Nam Oh, Yun Kyu Lim, Chun Soo Kim, Dong Ki Kim, Yon Su Choi, Kyungho Lee, Jung Pyo eng Research Support, Non-U.S. Gov't 2020/07/07 Clin J Am Soc Nephrol. 2020 Jun 8; 15(6):766-775. doi: 10.2215/CJN.06780619. Epub 2020 May 22"