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J Occup Environ Med

Title:		Nasal effects of a mixture of volatile organic compounds and their ozone oxidation products
Author(s):		Laumbach RJ; Fiedler N; Gardner CR; Laskin DL; Fan ZH; Zhang J; Weschler CJ; Lioy PJ; Devlin RB; Ohman-Strickland P; Kelly-McNeil K; Kipen HM;
Address:		"Environmental and Occupational Health Sciences Institute, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA. laumbach@eohsi.rutgers.edu"
Journal Title:		J Occup Environ Med
Year:		2005
Volume:		47
Issue:		11
Page Number:		1182 - 1189
DOI:		10.1097/01.jom.0000183338.95778.f0
ISSN/ISBN:		1076-2752 (Print) 1076-2752 (Linking)
Abstract:		"OBJECTIVE: Our objective was to determine if low levels of a mixture of volatile organic compounds (VOCs) and their ozone (O3) oxidation products, similar to what might be found in 'sick buildings,' cause nasal irritation and inflammation under controlled exposure conditions. METHODS: Healthy, nonsmoking women (n=130) completed 2-hour controlled exposures to VOCs, VOCs and O3, and a masked air 'MA' control in random order at least 1 week apart. VOCs and O3 concentrations were approximately 25 mg/m and approximately 40 ppb, respectively. Nasal symptoms were rated before, during, and after exposure. Nasal lavage fluid was analyzed for polymorphonuclear cells, total protein, interleukin-6, and interleukin-8. RESULTS: We found no significant differences in symptoms or markers of nasal inflammation between exposure conditions. CONCLUSIONS: Results suggest that VOCs and their oxidation products may not cause acute nasal effects at low concentrations"
Keywords:		"Adult Air Pollution, Indoor/*adverse effects Female Humans Nasal Lavage Fluid Nasal Mucosa/*physiopathology Odds Ratio Organic Chemicals/*adverse effects/chemistry Oxidants, Photochemical/*adverse effects Ozone/adverse effects/chemistry Volatilization;"
Notes:		"MedlineLaumbach, Robert J Fiedler, Nancy Gardner, Carol R Laskin, Debra L Fan, Zhi-Hua Zhang, Junfeng Weschler, Charles J Lioy, Paul J Devlin, Robert B Ohman-Strickland, Pamela Kelly-McNeil, Kathie Kipen, Howard M eng P30 ES005022/ES/NIEHS NIH HHS/ R01 ES004738/ES/NIEHS NIH HHS/ 2005/11/12 J Occup Environ Med. 2005 Nov; 47(11):1182-9. doi: 10.1097/01.jom.0000183338.95778.f0"