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J Crohns Colitis

Title:		The Diagnostic Utility of Volatile Organic Compounds in Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis
Author(s):		Krishnamoorthy A; Chandrapalan S; Ahmed M; Arasaradnam RP;
Address:		University of Warwick. Epsom and St Helier University Hospitals. University Hospital Coventry and Warwickshire
Journal Title:		J Crohns Colitis
Year:		2023
Volume:		20230804
Issue:
Page Number:		-
DOI:		10.1093/ecco-jcc/jjad132
ISSN/ISBN:		1876-4479 (Electronic) 1873-9946 (Linking)
Abstract:		"BACKGROUND: Volatile organic compounds (VOCs) show promise as potential biomarkers of for ulcerative colitis and Crohn's disease, two chronic idiopathic gastrointestinal disorders with diagnostic and management challenges. Non-invasive biomarkers aid early diagnosis and management. In this study we review studies of diagnostic accuracy of VOCs in inflammatory bowel disease. METHODS: A systematic search was carried out on the Pubmed and Scopus databases; with sixteen studies reviewed and meta-analysis carried out on ten. RESULTS: Meta analysis of 696 IBD cases against 605 controls revealed a pooled sensitivity and specificity of 87% (95% CI, 0.79 - 0.92) and 83% (95% CI, 0.73 - 0.90) respectively. AUC was 0.92. CONCLUSION: VOCs perform very well as non-invasive biomarkers of IBD; with much scope for future improvement and research"
Keywords:		biomarkers inflammatory bowel disease volatile organic compounds;
Notes:		"PublisherKrishnamoorthy, Ashwin Chandrapalan, Subashini Ahmed, Marriam Arasaradnam, Ramesh P eng England 2023/08/04 J Crohns Colitis. 2023 Aug 4:jjad132. doi: 10.1093/ecco-jcc/jjad132"