| Title: | Naloxone blocks the deterioration of male sexual behavior induced by alarm pheromone in rats |
| Author(s): | Kobayashi T; Kiyokawa Y; Arata S; Takeuchi Y; Mori Y; |
| Address: | "Laboratory of Veterinary Ethology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan" |
| ISSN/ISBN: | 1347-7439 (Electronic) 0916-7250 (Linking) |
| Abstract: | "Previously, we have demonstrated that the alarm pheromone deteriorates sexual behavior in male rats, which was blocked by pretreatment with a corticotrophin-releasing hormone (CRH) antagonist. Studies have shown that an opioid antagonist blocked the deterioration of male sexual behavior following intracerebroventricular administration of CRH. Therefore, possibly, the pheromone effects could also be mediated by the opioid system. In this study, we pretreated rats with naloxone, an opioid receptor antagonist, and examined the following sexual behavior modulations in male rats that were exposed to the alarm pheromone. Naloxone blocked the deterioration of sexual behavior in a dose-dependent manner. On the basis of these data and the results of the previous study, we conclude that the alarm pheromone activates the CRH system, which then activates the opioid system, to deteriorate male sexual behavior" |
| Keywords: | "Animals Female Male Naloxone/*pharmacology Narcotic Antagonists/*pharmacology Pheromones/*pharmacology Rats Sexual Behavior, Animal/*drug effects;" |
| Notes: | "MedlineKobayashi, Tatsuya Kiyokawa, Yasushi Arata, Sayaka Takeuchi, Yukari Mori, Yuji eng Research Support, Non-U.S. Gov't Japan 2013/02/01 J Vet Med Sci. 2013; 75(6):761-5. doi: 10.1292/jvms.12-0454. Epub 2013 Jan 30" |
