| Title: | Inhaled Volatile Molecules-Responsive TRP Channels as Non-Olfactory Receptors |
| Address: | "Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul 02792, Republic of Korea. Department of Medical and Digital Engineering, College of Engineering, Hanyang University, Seoul 04736, Republic of Korea. Department of Pharmacology, College of Medicine, Hanyang University, Seoul 04736, Republic of Korea" |
| DOI: | 10.4062/biomolther.2023.118 |
| ISSN/ISBN: | 1976-9148 (Print) 1976-9148 (Linking) |
| Abstract: | "Generally, odorant molecules are detected by olfactory receptors, which are specialized chemoreceptors expressed in olfactory neurons. Besides odorant molecules, certain volatile molecules can be inhaled through the respiratory tract, often leading to pathophysiological changes in the body. These inhaled molecules mediate cellular signaling through the activation of the Ca(2+)-permeable transient receptor potential (TRP) channels in peripheral tissues. This review provides a comprehensive overview of TRP channels that are involved in the detection and response to volatile molecules, including hazardous substances, anesthetics, plant-derived compounds, and pheromones. The review aims to shed light on the biological mechanisms underlying the sensing of inhaled volatile molecules. Therefore, this review will contribute to a better understanding of the roles of TRP channels in the response to inhaled molecules, providing insights into their implications for human health and disease" |
| Keywords: | Non-olfactory receptors Trpa1 Trpv1 Transient receptor potential channel Volatile organic compound; |
| Notes: | "PublisherKim, Hyungsup Kim, Minwoo Jang, Yongwoo eng Korea (South) 2023/08/08 Biomol Ther (Seoul). 2023 Aug 8. doi: 10.4062/biomolther.2023.118" |
