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Mol Cells

Title:		"The iron-responsive, GATA-type transcription factor Cir1 influences mating in Cryptococcus neoformans"
Author(s):		Jung WH; Kronstad JW;
Address:		"Department of Biotechnology, Chung-Ang University, Anseong 456-756, Korea"
Journal Title:		Mol Cells
Year:		2011
Volume:		20101125
Issue:		1
Page Number:		73 - 77
DOI:		10.1007/s10059-011-0011-0
ISSN/ISBN:		0219-1032 (Electronic) 1016-8478 (Print) 1016-8478 (Linking)
Abstract:		"Mating and sexual development have been associated with virulence in various fungal pathogens including Cryptococcus neoformans. This fungus is a significant pathogen of humans because it causes life-threatening cryptococcal meningitis in immunocompromised people such as AIDS patients. The virulence of C. neoformans is known to be associated with the mating type of the cells (alpha or a), with the alpha mating type being predominant among clinical isolates. However, the mechanisms by which mating and sexual development are controlled by environmental conditions and their relationship with virulence require further investigation. Cir1 is a GATA-type transcription factor that regulates the expression of genes required for utilization of essential metals such as iron and copper, and also genes required for major virulence factors including the polysaccharide capsule and melanin. Here we investigated the role of Cir1 in the mating of C. neoformans. Our results demonstrate that mutants lacking CIR1 are defective in mating, and that Cir1 contributes to copper mediated enhancement of sexual filamentation. Furthermore, we found that Cir1 influences the expression of mating pheromone genes suggesting that this protein plays a role in the early phase of sexual development on V8 mating medium"
Keywords:		"Copper/metabolism/pharmacology Cryptococcus neoformans/*metabolism/pathogenicity/physiology Fungal Proteins/genetics/*metabolism GATA Transcription Factors/genetics/*metabolism Genes, Mating Type, Fungal Iron/*metabolism Mutagenesis, Insertional Phenotype;"
Notes:		"MedlineJung, Won Hee Kronstad, James W eng R01 AI053721/AI/NIAID NIH HHS/ CAPMC/CIHR/Canada Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Korea (South) 2010/12/02 Mol Cells. 2011 Jan; 31(1):73-7. doi: 10.1007/s10059-011-0011-0. Epub 2010 Nov 25"