| Title: | Healthy scents: microbial volatiles as new frontier in antibiotic research? |
| Author(s): | Avalos M; van Wezel GP; Raaijmakers JM; Garbeva P; |
| Address: | "Institute of Biology, Leiden University, Sylviusweg 72, 2333 BE Leiden, The Netherlands. Institute of Biology, Leiden University, Sylviusweg 72, 2333 BE Leiden, The Netherlands; Netherlands Institute of Ecology, Droevendaalsesteeg 10, 6708 PB Wageningen, The Netherlands. Netherlands Institute of Ecology, Droevendaalsesteeg 10, 6708 PB Wageningen, The Netherlands. Electronic address: p.garbeva@nioo.knaw.nl" |
| DOI: | 10.1016/j.mib.2018.02.011 |
| ISSN/ISBN: | 1879-0364 (Electronic) 1369-5274 (Linking) |
| Abstract: | "Microorganisms represent a large and still resourceful pool for the discovery of novel compounds to combat antibiotic resistance in human and animal pathogens. The ability of microorganisms to produce structurally diverse volatile compounds has been known for decades, yet their biological functions and antimicrobial activities have only recently attracted attention. Various studies revealed that microbial volatiles can act as infochemicals in long-distance cross-kingdom communication as well as antimicrobials in competition and predation. Here, we review recent insights into the natural functions and modes of action of microbial volatiles and discuss their potential as a new class of antimicrobials and modulators of antibiotic resistance" |
| Keywords: | "Animals Anti-Bacterial Agents/*metabolism/pharmacology Bacteria/drug effects/genetics/*metabolism Bacterial Infections/drug therapy/*microbiology Drug Resistance, Bacterial Humans Volatile Organic Compounds/*metabolism/pharmacology;" |
| Notes: | "MedlineAvalos, Mariana van Wezel, Gilles P Raaijmakers, Jos M Garbeva, Paolina eng Research Support, Non-U.S. Gov't Review England 2018/03/16 Curr Opin Microbiol. 2018 Oct; 45:84-91. doi: 10.1016/j.mib.2018.02.011. Epub 2018 Mar 12" |
