| Title: | Furan and p-xylene as candidate biomarkers for prostate cancer |
| Author(s): | Jimenez-Pacheco A; Salinero-Bachiller M; Iribar MC; Lopez-Luque A; Mijan-Ortiz JL; Peinado JM; |
| Address: | "Department of Urology, Campus de la Salud Hospital, Granada, Spain. Department of de Biochemistry and Mol. Biol. III and Immunology, University of Granada, Granada, Spain. Department of Urology, Santa Ana Hospital (AGS Granada South), Motril, Granada, Spain. Department of de Biochemistry and Mol. Biol. III and Immunology, University of Granada, Granada, Spain. Electronic address: jpeinado@ugr.es" |
| DOI: | 10.1016/j.urolonc.2017.12.026 |
| ISSN/ISBN: | 1873-2496 (Electronic) 1078-1439 (Linking) |
| Abstract: | "BACKGROUND: Prostate cancer (PCa) is the most frequently diagnosed noncutaneous malignant tumor among males in the Western world. Prostate-specific antigen has been considered the most important biomarker for PCa detection; however, it lacks specificity, leading to the search for alternative biomarkers. Volatile organic compounds (VOCs) are released during cell metabolism and can be found in exhaled breath, urine, and other fluids. VOCs have been used in the diagnosis of lung, breast, ovarian, and colorectal cancers, among others. The objective of this study was to identify urinary VOCs that may be sensitive and specific biomarkers for PCa. METHODS: The study included 29 patients with PCa and 21 with benign prostatic hyperplasia. Urine samples were obtained from all participants before and after prostate massage. VOCs were identified by gas chromatography-mass spectrometry. IBM SPSS Statistics v.20 was used for statistical analysis. Sample normality and homogeneity of variances were studied and, according to the distribution normality, ANOVA or the Kruskal-Wallis test was applied to evaluate significant differences between groups. The Pearson test was used to establish correlations. RESULTS: Fifty-seven VOCs were identified. Samples gathered before prostate massage showed significant between-group differences in urinary levels of furan (P |
| Keywords: | "Aged Biomarkers, Tumor/*urine Case-Control Studies Follow-Up Studies Furans/*urine Humans Male Middle Aged Prognosis Prostatic Hyperplasia/*diagnosis/urine Prostatic Neoplasms/*diagnosis/urine Volatile Organic Compounds/*urine Xylenes/*urine Bph Gas chrom;" |
| Notes: | "MedlineJimenez-Pacheco, Antonio Salinero-Bachiller, Maria Iribar, Maria C Lopez-Luque, Alfonso Mijan-Ortiz, Jose L Peinado, Jose M eng 2018/02/06 Urol Oncol. 2018 May; 36(5):243.e21-243.e27. doi: 10.1016/j.urolonc.2017.12.026. Epub 2018 Feb 1" |
