| Title: | Mouse organic anion transporter 2 (mOat2) mediates the transport of short chain fatty acid propionate |
| Author(s): | Islam R; Anzai N; Ahmed N; Ellapan B; Jin CJ; Srivastava S; Miura D; Fukutomi T; Kanai Y; Endou H; |
| Address: | "Department of Pharmacology and Toxicology, Kyorin University School of Medicine, Japan" |
| ISSN/ISBN: | 1347-8613 (Print) 1347-8613 (Linking) |
| Abstract: | "In this study, we have elucidated that propionate, one of the short chain fatty acids (SCFAs), is the transport substrate for murine organic anion transporter 2 (mOat2), which is expressed in the kidneys and the liver. When expressed in Xenopus oocytes, mOat2-mediated [(3)H]PGE(2) transport was inhibited by three- to five-carbon SCFAs (C3 to C5). Among the SCFAs tested, propionate (3-carbon SCFA) was transported by mOat2 in a time-dependent manner. Since propionate is a potent glucogenic compound, Oat2 may be involved in the regulation of cellular metabolism through the transport of these metabolites in the kidneys and the liver" |
| Keywords: | "Animals Biological Transport Dinoprostone/metabolism Fatty Acids, Volatile/*metabolism Mice Organic Anion Transporters, Sodium-Independent/*physiology Propionates/*metabolism Xenopus;" |
| Notes: | "MedlineIslam, Rafiqul Anzai, Naohiko Ahmed, Nesar Ellapan, Babu Jin, Chun Ji Srivastava, Sunena Miura, Daisaku Fukutomi, Toshiyuki Kanai, Yoshikatsu Endou, Hitoshi eng Research Support, Non-U.S. Gov't Japan 2008/03/18 J Pharmacol Sci. 2008 Mar; 106(3):525-8. doi: 10.1254/jphs.sc0070291. Epub 2008 Mar 12" |
