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Nat Prod Res

Title:		Aromatic compounds from the endophytic fungus Asordaria conoidea and their allelochemical property using OSMAC strategy
Author(s):		Arruda GL; Moraes GKA; Junior AFC; Araujo AR; Chapla VM;
Address:		"Graduate Program in Chemistry, Federal University of Tocantins, UFT, Gurupi, Brazil. Graduate Program in Biotechnology, Federal University of Tocantins, UFT, Gurupi, Brazil. Organic Chemistry Department, Sao Paulo State University, UNESP, Chemistry Institute, Araraquara, Brazil"
Journal Title:		Nat Prod Res
Year:		2022
Volume:		20210304
Issue:		15
Page Number:		3999 - 4002
DOI:		10.1080/14786419.2021.1892098
ISSN/ISBN:		1478-6427 (Electronic) 1478-6419 (Linking)
Abstract:		"Endophytic fungi are biodiverse and alternative source of bioactive compounds, due their different abilities of genetic expression and alteration of biosynthetic pathway when submitted to different culture conditions. The metabolic profile of three different crude extracts (A, B and C), obtained from the endophytic fungus Asordaria conoidea, were evaluated by HPLC and (1)H NMR. Antioxidant and allelochemical activity were also evaluated. OSMAC diversified the metabolic production, mainly in the solid culture, where the tyrosol, 4-hydroxybenzaldehyde, 2-phenylacetamide and vanillic acid were isolated. The structures of the compounds were elucidated mainly by NMR. Extracts had antioxidant potential, however, only Extract C showed allelochemical activity, as inhibition of 65.5% in growth. This study confirms the efficiency of the OSMAC platform in producing extracts of different properties and compounds. Herein the A. conoidea was isolated for the first time as an endophytic microorganism"
Keywords:		Antioxidants/pharmacology Fungi Organic Chemicals *Pheromones *Sordariales Cochlospermum regium Endophytic fungus allelochemical activity aromatic compounds fungi metabolism;
Notes:		"MedlineArruda, Gabriel Leda de Moraes, Gleys Kellen Aquino de Junior, Aloisio Freitas Chagas Araujo, Angela Regina Chapla, Vanessa Mara eng England 2021/03/06 Nat Prod Res. 2022 Aug; 36(15):3999-4002. doi: 10.1080/14786419.2021.1892098. Epub 2021 Mar 4"