| Title: | The LINA Study: Higher Sensitivity of Infant Compared to Maternal Eosinophil/Basophil Progenitors to Indoor Chemical Exposures |
| Author(s): | Hornig F; Kohajda T; Roder S; Herberth G; von Bergen M; Borte M; Diez U; Rolle-Kampczyk U; Simon JC; Denburg JA; Lehmann I; Junge KM; |
| Address: | "Helmholtz Centre for Environmental Research (UFZ), Leipzig, Department of Environmental Immunology, Permoserstrasse 15, 04318 Leipzig, Germany; Leipzig Research Center for Civilization Diseases (LIFE), University of Leipzig, Philipp-Rosenthal-Strasse 27, 04103 Leipzig, Germany. Helmholtz Centre for Environmental Research (UFZ), Leipzig, Department of Metabolomics, Permoserstrasse 15, 04318 Leipzig, Germany. Helmholtz Centre for Environmental Research (UFZ), Leipzig, Core Facility Studies, Permoserstrasse 15, 04318 Leipzig, Germany. Helmholtz Centre for Environmental Research (UFZ), Leipzig, Department of Environmental Immunology, Permoserstrasse 15, 04318 Leipzig, Germany. Helmholtz Centre for Environmental Research (UFZ), Leipzig, Department of Metabolomics, Permoserstrasse 15, 04318 Leipzig, Germany; Helmholtz Centre for Environmental Research (UFZ), Leipzig, Department of Proteomics, Permoserstrasse 15, 04318 Leipzig, Germany; Department of Biotechnology, Chemistry and Environmental Engineering, Aalborg University, Niels Jernes Vej 10, 9220 Aalborg East, Denmark. Children's Hospital, Municipal Hospital 'St. Georg', Academic Teaching Hospital of the University of Leipzig, Delitzscher Strasse 141, 04129 Leipzig, Germany. University Hospital of Leipzig, Department of Dermatology, Venereology and Allergology, Philipp-Rosenthal-Strasse 23, Haus 10, 04103 Leipzig, Germany. Department of Medicine, Division of Clinical Immunology and Allergy, McMaster University, 1200 Main Street West, Hamilton, ON, Canada L8N 3Z5" |
| ISSN/ISBN: | 1687-9813 (Electronic) 1687-9805 (Print) 1687-9805 (Linking) |
| Abstract: | "PURPOSE: Enhanced eosinophil/basophil (Eo/B) progenitor cell levels are known to be associated with allergic inflammation and atopy risk. The aim of the present study was to investigate the influence of different indoor exposures on the recruitment and differentiation of Eo/B progenitors in mother-child pairs. METHODS: In 68 mother-child pairs of the LINA study peripheral blood mononuclear cells were used to assess Eo/B colony forming units (CFUs). Information about disease outcomes and indoor exposures was obtained from questionnaires. Indoor concentrations of volatile organic compounds (VOCs) were measured by passive sampling. RESULTS: Infant's Eo/B CFUs were positively associated with exposure to tobacco smoke, disinfectants, or VOCs. In contrast, for maternal Eo/B CFUs, only a few associations were seen. Higher numbers of infant Eo/B CFUs were observed in children with wheezing symptoms within the second year of life. CONCLUSIONS: We demonstrate that infant's hematopoietic cells seem to respond with more sensitivity to environmental exposure compared to maternal cells. At least in infants, an activation of these hematopoietic cells by environmental exposure could contribute to an enhanced risk for the development of respiratory outcomes" |
| Keywords: | "Adult Age Factors Air Pollutants/*adverse effects Air Pollution, Indoor/*adverse effects Basophils/immunology Child, Preschool *Environmental Exposure Eosinophils/immunology Female Granulocyte Precursor Cells/*immunology Humans Infant Leukocytes, Mononucl;" |
| Notes: | "MedlineHornig, Friederike Kohajda, Tibor Roder, Stefan Herberth, Gunda von Bergen, Martin Borte, Michael Diez, Ulrike Rolle-Kampczyk, Ulrike Simon, Jan-C Denburg, Judah A Lehmann, Irina Junge, Kristin M eng Research Support, Non-U.S. Gov't 2016/06/18 J Environ Public Health. 2016; 2016:5293932. doi: 10.1155/2016/5293932. Epub 2016 May 26" |
