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Cell

Title:		Modifiers of position effect are shared between telomeric and silent mating-type loci in S. cerevisiae
Author(s):		Aparicio OM; Billington BL; Gottschling DE;
Address:		"Department of Molecular Genetics and Cell Biology, University of Chicago, Illinois 60637"
Journal Title:		Cell
Year:		1991
Volume:		66
Issue:		6
Page Number:		1279 - 1287
DOI:		10.1016/0092-8674(91)90049-5
ISSN/ISBN:		0092-8674 (Print) 0092-8674 (Linking)
Abstract:		"Genes placed near telomeres in S. cerevisiae succumb to position-effect variegation. SIR2, SIR3, SIR4, NAT1, ARD1, and HHF2 (histone H4) were identified as modifiers of the position effect at telomeres, since transcriptional repression near telomeres was no longer observed when any of the modifier genes were mutated. These genes, in addition to SIR1, have previously been shown to repress transcription at the silent mating loci, HML and HMR. However, there were differences between transcriptional silencing at telomeres and the HM loci, as demonstrated by suppressor analysis and the lack of involvement of SIR1 in telomeric silencing. These findings provide insights into telomeric structure and function that are likely to apply to many eukaryotes. In addition, the distinctions between telomeres and the HM loci suggest a hierarchy of chromosomal silencing in S. cerevisiae"
Keywords:		"Chromosomes, Fungal/physiology/*ultrastructure *Gene Expression Regulation, Fungal *Genes, Fungal Genes, Regulator Histones/genetics Mating Factor Peptides/genetics Saccharomyces cerevisiae/*genetics Transcription, Genetic;"
Notes:		"MedlineAparicio, O M Billington, B L Gottschling, D E eng CA14599-16/CA/NCI NIH HHS/ GM43893/GM/NIGMS NIH HHS/ Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S. 1991/09/20 Cell. 1991 Sep 20; 66(6):1279-87. doi: 10.1016/0092-8674(91)90049-5"