| Title: | Ionic Liquids Toxicity-Benefits and Threats |
| Address: | "Department of Analytical Chemistry, Medical University of Lublin, Chodzki 4a, 20-093 Lublin, Poland. Medical University of Lublin, Faculty of Medicine, Aleje Raclawickie 1, 20-059 Lublin, Poland" |
| ISSN/ISBN: | 1422-0067 (Electronic) 1422-0067 (Linking) |
| Abstract: | "Ionic liquids (ILs) are solvents with salt structures. Typically, they contain organic cations (ammonium, imidazolium, pyridinium, piperidinium or pyrrolidinium), and halogen, fluorinated or organic anions. While ILs are considered to be environmentally-friendly compounds, only a few reasons support this claim. This is because of high thermal stability, and negligible pressure at room temperature which makes them non-volatile, therefore preventing the release of ILs into the atmosphere. The expansion of the range of applications of ILs in many chemical industry fields has led to a growing threat of contamination of the aquatic and terrestrial environments by these compounds. As the possibility of the release of ILs into the environment s grow systematically, there is an increasing and urgent obligation to determine their toxic and antimicrobial influence on the environment. Many bioassays were carried out to evaluate the (eco)toxicity and biodegradability of ILs. Most of them have questioned their 'green' features as ILs turned out to be toxic towards organisms from varied trophic levels. Therefore, there is a need for a new biodegradable, less toxic 'greener' ILs. This review presents the potential risks to the environment linked to the application of ILs. These are the following: cytotoxicity evaluated by the use of human cells, toxicity manifesting in aqueous and terrestrial environments. The studies proving the relation between structures versus toxicity for ILs with special emphasis on directions suitable for designing safer ILs synthesized from renewable sources are also presented. The representants of a new generation of easily biodegradable ILs derivatives of amino acids, sugars, choline, and bicyclic monoterpene moiety are collected. Some benefits of using ILs in medicine, agriculture, and the bio-processing industry are also presented" |
| Keywords: | "Biodegradation, Environmental Environmental Pollutants/chemistry/toxicity Ionic Liquids/*chemistry/*toxicity Molecular Structure Quantitative Structure-Activity Relationship (eco)toxicity Qsar/qspr bioprocessing ionic liquids medical applications;" |
| Notes: | "MedlineFlieger, Jolanta Flieger, Michal eng Review Switzerland 2020/09/03 Int J Mol Sci. 2020 Aug 29; 21(17):6267. doi: 10.3390/ijms21176267" |
