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Int J Cancer

Title:		Electronic nose can discriminate colorectal carcinoma and advanced adenomas by fecal volatile biomarker analysis: proof of principle study
Author(s):		De Meij TG; Larbi IB; van der Schee MP; Lentferink YE; Paff T; Terhaar Sive Droste JS; Mulder CJ; van Bodegraven AA; de Boer NK;
Address:		"Department of Paediatric Gastroenterology, VU University medical centre, Amsterdam, The Netherlands"
Journal Title:		Int J Cancer
Year:		2014
Volume:		20130902
Issue:		5
Page Number:		1132 - 1138
DOI:		10.1002/ijc.28446
ISSN/ISBN:		1097-0215 (Electronic) 0020-7136 (Linking)
Abstract:		"In the course and prognosis of colorectal cancer (CRC), early detection and treatment are essential factors. Fecal immunochemical tests (FITs) are currently the most commonly used non-invasive screening tests for CRC and premalignant (advanced) adenomas, however, with restricted sensitivity. We hypothesized that fecal volatile organic compounds (VOCs) may serve as a diagnostic biomarker of CRC and adenomas. In this proof of concept study, we aimed to assess disease-specific VOC smellprints in fecal gas to distinguish patients with CRC and advanced adenomas from healthy controls. Fecal samples of patients who were scheduled to undergo an elective colonoscopy were collected. An electronic nose (Cyranose 320) was used to measure VOC patterns in fecal gas from patients with histopathologically proven CRC, with advanced adenomas and from controls (no abnormalities seen at colonoscopy). Receiver operator characteristic curves and corresponding sensitivity and specificity for detection of CRC and advanced adenomas were calculated. A total of 157 stool samples (40 patients with CRC, 60 patients with advanced adenomas, and 57 healthy controls) were analyzed by electronic nose. Fecal VOC profiles of patients with CRC differed significantly from controls (area under curve +/- 95%CI, p-value, sensitivity, specificity; 0.92 +/- 0.03, <0.001, 85%, 87%). Also VOC profiles of patients with advanced adenomas could be discriminated from controls (0.79 +/- 0.04, <0.001, 62%, 86%). The results of this proof of concept study suggest that fecal gas analysis by an electronic nose seems to hold promise as a novel screening tool for the (early) detection of advanced neoplasia and CRC"
Keywords:		"Adenoma/*diagnosis Adult Aged Biomarkers, Tumor/*analysis Colorectal Neoplasms/*diagnosis *Electronic Nose Feces/chemistry Female Humans Male Middle Aged ROC Curve Sensitivity and Specificity Volatile Organic Compounds/*analysis adenoma colorectal cancer;"
Notes:		"Medlinede Meij, Tim G Larbi, Ilhame Ben van der Schee, Marc P Lentferink, Yvette E Paff, Tamara Terhaar Sive Droste, Jochim S Mulder, Chris J van Bodegraven, Adriaan A de Boer, Nanne K eng 2013/08/21 Int J Cancer. 2014 Mar 1; 134(5):1132-8. doi: 10.1002/ijc.28446. Epub 2013 Sep 2"