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PLoS One

Title:		Clinical trial and detection of SARS-CoV-2 by a commercial breath analysis test based on Terahertz technology
Author(s):		De Almeida MB; Aharonov-Nadborny R; Gabbai E; Palka AP; Schiavo L; Esmanhoto E; Riediger I; Rocha J; Margulis A; Loureiro M; Pettan-Brewer C; Kmetiuk LB; De Barros-Filho IR; Biondo AW;
Address:		"Parana Institute of Technology-TECPAR, Curitiba, Parana State, Brazil. TeraGroup Terahertz Ltd, Herzliya, Tel Aviv District, Israel. Parana State Reference Laboratory, Sao Jose dos Pinhais, Parana State, Brazil. Department of Infectious Diseases, Pontifical Catholic University, Curitiba, Parana State, Brazil. Department of Comparative Medicine, School of Medicine, University of Washington, Seattle, WA, United States of America. Department of Veterinary Medicine, Federal University of Parana State, Curitiba, Parana State, Brazil"
Journal Title:		PLoS One
Year:		2022
Volume:		20220920
Issue:		9
Page Number:		e0273506 -
DOI:		10.1371/journal.pone.0273506
ISSN/ISBN:		1932-6203 (Electronic) 1932-6203 (Linking)
Abstract:		"Public health threats such as the current COVID-19 pandemics have required prompt action by the local, national, and international authorities. Rapid and noninvasive diagnostic methods may provide on-site detection and immediate social isolation, used as tools to rapidly control virus spreading. Accordingly, the aim of the present study was to evaluate a commercial breath analysis test (TERA.Bio(R)) and deterministic algorithm for detecting the SARS-CoV-2 spectral signature of Volatile Organic Compounds present in exhaled air samples of suspicious persons from southern Brazil. A casuistic total of 70 infected and 500 non-infected patients were sampled, tested, and results later compared to RT-qPCR as gold standard. Overall, the test showed 92.6% sensitivity and 96.0% specificity. No statistical correlation was observed between SARS-CoV-2 positivity and infection by other respiratory diseases. Further studies should focus on infection monitoring among asymptomatic persons. In conclusion, the breath analysis test herein may be used as a fast, on-site, and easy-to-apply screening method for diagnosing COVID-19"
Keywords:		Brazil *COVID-19/diagnosis Humans SARS-CoV-2 Technology *Volatile Organic Compounds;
Notes:		"MedlineDe Almeida, Meila Bastos Aharonov-Nadborny, Regina Gabbai, Eran Palka, Ana Paula Schiavo, Leticia Esmanhoto, Elis Riediger, Irina Rocha, Jaime Margulis, Ariel Loureiro, Marcelo Pettan-Brewer, Christina Kmetiuk, Louise Bach De Barros-Filho, Ivan Roque Biondo, Alexander Welker eng Research Support, Non-U.S. Gov't 2022/09/21 PLoS One. 2022 Sep 20; 17(9):e0273506. doi: 10.1371/journal.pone.0273506. eCollection 2022"