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Insects

Title:		Dynamic Roles of Insect Carboxyl/Cholinesterases in Chemical Adaptation
Author(s):		Cruse C; Moural TW; Zhu F;
Address:		"Department of Entomology, Pennsylvania State University, University Park, State College, PA 16802, USA. Huck Institutes of the Life Sciences, Pennsylvania State University, University Park, State College, PA 16802, USA"
Journal Title:		Insects
Year:		2023
Volume:		20230216
Issue:		2
Page Number:		-
DOI:		10.3390/insects14020194
ISSN/ISBN:		2075-4450 (Print) 2075-4450 (Electronic) 2075-4450 (Linking)
Abstract:		"Insects have evolved several intricate defense mechanisms to adapt to their chemical environment. Due to their versatile capabilities in hydrolytic biotransformation, insect carboxyl/cholinesterases (CCEs) play vital roles in the development of pesticide resistance, facilitating the adaptation of insects to their host plants, and manipulating insect behaviors through the olfaction system. CCEs confer insecticide resistance through the mechanisms of qualitative or quantitative changes of CCE-mediated enhanced metabolism or target-site insensitivity, and may contribute to the host plant adaptation. CCEs represent the first odorant-degrading enzymes (ODEs) discovered to degrade insect pheromones and plant odors and remain the most promising ODE candidates. Here, we summarize insect CCE classification, currently characterized insect CCE protein structure characteristics, and the dynamic roles of insect CCEs in chemical adaptation"
Keywords:		catalytic triad hydrolysis metabolic detoxification odorant-degrading enzymes olfaction pesticide resistance sequestration;
Notes:		"PubMed-not-MEDLINECruse, Casey Moural, Timothy Walter Zhu, Fang eng NSF CAREER IOS-2144082/National Science Foundation/ Review Switzerland 2023/02/26 Insects. 2023 Feb 16; 14(2):194. doi: 10.3390/insects14020194"