| Title: | Phytochemistry and Pharmacology of Eleutherococcus sessiliflorus (Rupr. & Maxim.) S.Y.Hu: A Review |
| Author(s): | Sun H; Feng J; Sun Y; Sun S; Li L; Zhu J; Zang H; |
| Address: | "Green Medicinal Chemistry Laboratory, School of Pharmacy and Medicine, Tonghua Normal University, Tonghua 134002, China. College of Pharmacy, Yanbian University, Yanji 133000, China. Key Laboratory of Evaluation and Application of Changbai Mountain Biological Gerplasm Resources of Jilin Province, Tonghua 134002, China" |
| DOI: | 10.3390/molecules28186564 |
| ISSN/ISBN: | 1420-3049 (Electronic) 1420-3049 (Linking) |
| Abstract: | "Eleutherococcus sessiliflorus (Rupr. & Maxim.) S.Y.Hu (E. sessiliflorus), a member of the Araliaceae family, is a valuable plant widely used for medicinal and dietary purposes. The tender shoots of E. sessiliflorus are commonly consumed as a staple wild vegetable. The fruits of E. sessiliflorus, known for their rich flavor, play a crucial role in the production of beverages and fruit wines. The root barks of E. sessiliflorus are renowned for their therapeutic effects, including dispelling wind and dampness, strengthening tendons and bones, promoting blood circulation, and removing stasis. To compile a comprehensive collection of information on E. sessiliflorus, extensive searches were conducted in databases such as Web of Science, PubMed, ProQuest, and CNKI. This review aims to provide a detailed exposition of E. sessiliflorus from various perspectives, including phytochemistry and pharmacological effects, to lay a solid foundation for further investigations into its potential uses. Moreover, this review aims to introduce innovative ideas for the rational utilization of E. sessiliflorus resources and the efficient development of related products. To date, a total of 314 compounds have been isolated and identified from E. sessiliflorus, encompassing terpenoids, phenylpropanoids, flavonoids, volatile oils, organic acids and their esters, nitrogenous compounds, quinones, phenolics, and carbohydrates. Among these, triterpenoids and phenylpropanoids are the primary bioactive components, with E. sessiliflorus containing unique 3,4-seco-lupane triterpenoids. These compounds have demonstrated promising properties such as anti-oxidative stress, anti-aging, antiplatelet aggregation, and antitumor effects. Additionally, they show potential in improving glucose metabolism, cardiovascular systems, and immune systems. Despite some existing basic research on E. sessiliflorus, further investigations are required to enhance our understanding of its mechanisms of action, quality assessment, and formulation studies. A more comprehensive investigation into E. sessiliflorus is warranted to delve deeper into its mechanisms of action and potentially expand its pharmaceutical resources, thus facilitating its development and utilization" |
| Keywords: | *Eleutherococcus/chemistry Plant Extracts/chemistry *Triterpenes/chemistry Fruit/chemistry Esters/analysis Phytochemicals/analysis Ethnopharmacology Eleutherococcus sessiliflorus (Rupr.& Maxim.) S.Y.Hu herbal metabolites pharmacological effects triterpen; |
| Notes: | "MedlineSun, Hui Feng, Jiaxin Sun, Yue Sun, Shuang Li, Li Zhu, Junyi Zang, Hao eng YDZJ202301ZYTS171/Science and Technology Development Plan Project of Jilin Province/ YDZJ202201ZYTS186/Science and Technology Development Plan Project of Jilin Province/ Review Switzerland 2023/09/28 Molecules. 2023 Sep 11; 28(18):6564. doi: 10.3390/molecules28186564" |
