| Title: | A profile of volatile organic compounds in exhaled air as a potential non-invasive biomarker for liver cirrhosis |
| Author(s): | Pijls KE; Smolinska A; Jonkers DM; Dallinga JW; Masclee AA; Koek GH; van Schooten FJ; |
| Address: | "Division Gastroenterology-Hepatology, Department of Internal Medicine, School for Nutrition and Metabolism Translational Research in Metabolism (NUTRIM), Maastricht University Medical Center, the Netherlands. Department of Pharmacology and Toxicology, School for Nutrition and Translational Research in Metabolism (NUTRIM), Maastricht University Medical Center, the Netherlands. Top Institute Food and Nutrition (TIFN), Wageningen, the Netherlands" |
| ISSN/ISBN: | 2045-2322 (Electronic) 2045-2322 (Linking) |
| Abstract: | "Early diagnosis of liver cirrhosis may prevent progression and development of complications. Liver biopsy is the current standard, but is invasive and associated with morbidity. We aimed to identify exhaled volatiles within a heterogeneous group of chronic liver disease (CLD) patients that discriminates those with compensated cirrhosis (CIR) from those without cirrhosis, and compare this with serological markers. Breath samples were collected from 87 CLD and 34 CIR patients. Volatiles in exhaled air were measured by gas chromatography mass spectrometry. Discriminant Analysis was performed to identify the optimal panel of serological markers and VOCs for classifying our patients using a random training set of 27 CIR and 27 CLD patients. Two randomly selected independent internal validation sets and permutation test were used to validate the model. 5 serological markers were found to distinguish CIR and CLD patients with a sensitivity of 0.71 and specificity of 0.84. A set of 11 volatiles discriminated CIR from CLD patients with sensitivity of 0.83 and specificity of 0.87. Combining both did not further improve accuracy. A specific exhaled volatile profile can predict the presence of compensated cirrhosis among CLD patients with a higher accuracy than serological markers and can aid in reducing liver biopsies" |
| Keywords: | Adolescent Adult Aged Biomarkers Case-Control Studies *Exhalation Female Humans Liver Cirrhosis/blood/*diagnosis/etiology/*metabolism Liver Diseases/diagnosis/etiology/metabolism Male Middle Aged ROC Curve *Volatile Organic Compounds Young Adult; |
| Notes: | "MedlinePijls, Kirsten E Smolinska, Agnieszka Jonkers, Daisy M A E Dallinga, Jan W Masclee, Ad A M Koek, Ger H van Schooten, Frederik-Jan eng Research Support, Non-U.S. Gov't England 2016/01/30 Sci Rep. 2016 Jan 29; 6:19903. doi: 10.1038/srep19903" |
