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Can J Microbiol

Title:		"Volatile organic compounds kill the white-nose syndrome fungus, Pseudogymnoascus destructans, in hibernaculum sediment"
Author(s):		Micalizzi EW; Smith ML;
Address:		"Department of Biology, Nesbitt Building, Carleton University, 1125 Colonel By Drive, Ottawa, ON K1S 5B6, Canada"
Journal Title:		Can J Microbiol
Year:		2020
Volume:		20200602
Issue:		10
Page Number:		593 - 599
DOI:		10.1139/cjm-2020-0071
ISSN/ISBN:		1480-3275 (Electronic) 0008-4166 (Linking)
Abstract:		"Pseudogymnoascus destructans, the fungal pathogen that causes white-nose syndrome, has killed millions of bats across eastern North America and continues to threaten new bat populations. The spread and persistence of P. destructans has likely been worsened by the ability of this fungus to grow as a saprotroph in the hibernaculum environment. Reducing the environmental growth of P. destructans may improve bat survival. Volatile organic compounds (VOCs) are attractive candidates to target environmental P. destructans, as they can permeate through textured environments that may be difficult to thoroughly contact with other control mechanisms. We tested in hibernaculum sediment the performance of VOCs that were previously shown to inhibit P. destructans growth in agar cultures and examined the inhibition kinetics and specificity of these compounds. Three VOCs, 2-methyl-1-butanol, 2-methyl-1-propanol, and 1-pentanol, were fungicidal towards P. destructans in hibernaculum sediment, fast-acting, and had greater effects against P. destructans than other Pseudogymnoascus species. Our results suggest that use of these VOCs may be considered further as an effective management strategy to reduce the environmental exposure of bats to P. destructans in hibernacula"
Keywords:		"Animals Ascomycota/*drug effects/physiology Chiroptera/microbiology Fungicides, Industrial/*pharmacology Geologic Sediments/*microbiology Nose Diseases/microbiology/veterinary Volatile Organic Compounds/*pharmacology Pseudogymnoascus destructans composes;"
Notes:		"MedlineMicalizzi, Emma W Smith, Myron L eng Canada 2020/06/03 Can J Microbiol. 2020 Oct; 66(10):593-599. doi: 10.1139/cjm-2020-0071. Epub 2020 Jun 2"