| Title: | Pheromone-inducible conjugation in Enterococcus faecalis: a model for the evolution of biological complexity? |
| Author(s): | Kozlowicz BK; Dworkin M; Dunny GM; |
| Address: | "Department of Microbiology, University of Minnesota Medical School, 1460 Mayo Bldg., MMC196, 420 Delaware St., SE, Minneapolis, MN 55455, USA" |
| DOI: | 10.1016/j.ijmm.2006.01.040 |
| ISSN/ISBN: | 1438-4221 (Print) 1618-0607 (Electronic) 1438-4221 (Linking) |
| Abstract: | "Pheromone-inducible transfer of the plasmid pCF10 in Enterococcus faecalis is regulated using a complicated network of proteins and RNAs. The plasmid itself has been assembled from parts garnered from a variety of sources, and many aspects of the system resemble a biological kluge. Recently several new functions of various pCF10 gene products that participate in regulation of plasmid transfer have been identified. The results indicate that selective pressures controlling the evolution of the plasmid have produced a highly complex regulatory network with multiple biological functions that may serve well as a model for the evolution of biological complexity" |
| Keywords: | "Bacterial Proteins/physiology Biological Evolution *Conjugation, Genetic Enterococcus faecalis/*genetics/pathogenicity/*physiology Gene Transfer, Horizontal Models, Biological Oligopeptides/genetics/*pharmacology Pheromones/genetics/*pharmacology Plasmids;" |
| Notes: | "MedlineKozlowicz, Briana K Dworkin, Martin Dunny, Gary M eng T32 GM008347/GM/NIGMS NIH HHS/ R01 HL051987-12/HL/NHLBI NIH HHS/ HL51987/HL/NHLBI NIH HHS/ GM49530/GM/NIGMS NIH HHS/ R01 GM049530/GM/NIGMS NIH HHS/ R01 GM049530-20/GM/NIGMS NIH HHS/ R01 HL051987/HL/NHLBI NIH HHS/ T32 GM08347/GM/NIGMS NIH HHS/ R01 AI058134/AI/NIAID NIH HHS/ Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review Germany 2006/03/01 Int J Med Microbiol. 2006 Apr; 296(2-3):141-7. doi: 10.1016/j.ijmm.2006.01.040. Epub 2006 Feb 28" |
