| Title: | Olfactory regulation of the sexual behavior and reproductive physiology of the laboratory mouse: effects and neural mechanisms |
| Author(s): | Kelliher KR; Wersinger SR; |
| Address: | "Department of Biological Sciences, University of Idaho, Moscow, USA" |
| ISSN/ISBN: | 1930-6180 (Electronic) 1084-2020 (Linking) |
| Abstract: | "In many species, chemical compounds emitted by conspecifics exert profound effects on reproductive physiology and sexual behavior. This is particularly true in the mouse, where such cues advance and delay puberty, suppress and facilitate estrous cycles, and cause the early termination of pregnancy. They also facilitate sexual behavior and inform mate selection. The mouse has a rich and complex repertoire of social behaviors. The technologies of molecular genetics are well developed in the mouse. Gene expression can be experimentally manipulated in the mouse relatively easily and in a time- and tissue-specific manner. Thus, the mouse is an excellent model in which to investigate the genetic, neural, and hormonal bases by which chemical compounds released by other mice affect physiology and behavior. These chemical cues are detected and processed by the olfactory system and other specialized but less well characterized sensory organs. The sensory information reaches brain regions that regulate hormone levels as well as those that are involved in behavior and alters the function of these brain regions. The effects of these chemical compounds have important implications for the laboratory animal facility as well as for researchers. We begin with an overview of the basic structure and function of the olfactory system and of the connections among brain regions that receive olfactory stimuli. We discuss the effects of chemosensory cues on the behavior and physiology of the organism along with what is known about the neural and hormonal mechanisms underlying these effects. We also describe some of the implications for the laboratory animal facility" |
| Keywords: | "Animals Brain/anatomy & histology/physiology Cues Estrous Cycle Female Male Mice Olfactory Perception/*physiology Pheromones/physiology Pregnancy *Sexual Behavior, Animal Sexual Maturation Social Behavior Vomeronasal Organ/physiology;" |
| Notes: | "MedlineKelliher, Kevin R Wersinger, Scott R eng Review England 2008/12/25 ILAR J. 2009; 50(1):28-42. doi: 10.1093/ilar.50.1.28" |
