| Title: | Volatile organic compounds from exhaled breath in schizophrenia |
| Author(s): | Jiang C; Dobrowolny H; Gescher DM; Meyer-Lotz G; Steiner J; Hoeschen C; Frodl T; |
| Address: | "Department of Psychiatry and Psychotherapy, Otto von Guericke University Magdeburg (OVGU), Magdeburg, Germany. Department of Psychiatry, Psychotherapy and Psychosomatics, University Hospital, RWTH Aachen, Aachen, Germany. Institute of Medical Engineering, Otto von Guericke University Magdeburg (OVGU), Magdeburg, Germany" |
| DOI: | 10.1080/15622975.2022.2040052 |
| ISSN/ISBN: | 1814-1412 (Electronic) 1562-2975 (Linking) |
| Abstract: | "OBJECTIVES: This study aims to find out whether volatile organic compounds (VOCs) from exhaled breath differ significantly between patients with schizophrenia and healthy controls and whether it might be possible to create an algorithm that can predict the likelihood of suffering from schizophrenia. METHODS: To test this theory, a group of patients with clinically diagnosed acute schizophrenia as well as a healthy comparison group has been investigated, which have given breath samples during awakening response right after awakening, after 30 min and after 60 min. The VOCs were measured using Proton-Transfer-Reaction Mass Spectrometry. RESULTS: By applying bootstrap with mixed model analysis (n = 1000), we detected 10 signatures (m/z 39, 40, 59, 60, 69, 70, 74, 85, 88 and 90) showing reduced concentration in patients with schizophrenia compared to healthy controls. These could safely discriminate patients and controls and were not influenced by smoking. Logistic regression forward method achieved an area under the receiver operating characteristic curve (AUC) of 0.91 and an accuracy of 82% and a machine learning approach with bartMachine an AUC of 0.96 and an accuracy of 91%. CONCLUSION: Breath gas analysis is easy to apply, well tolerated and seems to be a promising candidate for further studies on diagnostic and predictive clinical utility" |
| Keywords: | Humans *Volatile Organic Compounds/analysis *Schizophrenia/diagnosis Exhalation Breath Tests/methods Mass Spectrometry/methods Schizophrenia breath gas classification clinical utility volatile organic compounds; |
| Notes: | "MedlineJiang, Carina Dobrowolny, Henrik Gescher, Dorothee Maria Meyer-Lotz, Gabriela Steiner, Johann Hoeschen, Christoph Frodl, Thomas eng England 2022/02/17 World J Biol Psychiatry. 2022 Dec; 23(10):773-784. doi: 10.1080/15622975.2022.2040052. Epub 2022 Mar 9" |
