| Title: | "Use of faecal volatile organic compound analysis for ante-mortem discrimination between CWD-positive, -negative exposed, and -known negative white-tailed deer (Odocoileus virginianus)" |
| Author(s): | Ellis CK; Volker SF; Griffin DL; VerCauteren KC; Nichols TA; |
| Address: | "a Feral Swine Project , USDA-APHIS-WS-National Wildlife Research Center , Fort Collins , CO , USA. b Analytical Chemistry Department , USDA-APHIS-WS-National Wildlife Research Center , Fort Collins , CO , USA. c BioLaboratories , USDA-APHIS-WS-National Wildlife Research Center , Fort Collins , CO , USA. d USDA-APHIS-VS-Cervid Health Program , Fort Collins , CO , USA" |
| DOI: | 10.1080/19336896.2019.1607462 |
| ISSN/ISBN: | 1933-690X (Electronic) 1933-6896 (Print) 1933-6896 (Linking) |
| Abstract: | "Chronic wasting disease (CWD) is a naturally occurring infectious, fatal, transmissible spongiform encephalopathy of cervids. Currently, disease confirmation relies on post-mortem detection of infectious prions in the medial retropharyngeal lymph nodes or obex in the brain via immunohistochemistry (IHC). Detection of CWD in living animals using this method is impractical, and IHC and other experimental assays are not reliable in detecting low concentrations of prion present in biofluids or faeces. Here, we evaluate the capability of faecal volatile organic compound analysis to discriminate between CWD-positive and -exposed white-tailed deer located at two positive cervid farms, and two groups of CWD-negative deer from two separate disease-free farms" |
| Keywords: | "Animals;Animals *Deer/physiology Feces/*chemistry Prions/*analysis Volatile Organic Compounds/*analysis Wasting Disease, Chronic/*diagnosis Cwd Chronic wasting disease Voc ante-mortem testing fecal volatile organic compound prion;" |
| Notes: | "MedlineEllis, Christine K Volker, Steven F Griffin, Doreen L VerCauteren, Kurt C Nichols, Tracy A eng Research Support, U.S. Gov't, Non-P.H.S. 2019/04/30 Prion. 2019 Jan; 13(1):94-105. doi: 10.1080/19336896.2019.1607462" |
