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Nat Ecol Evol

Title:		A single gene integrates sex and hormone regulators into sexual attractiveness
Author(s):		Chen N; Liu YJ; Fan YL; Pei XJ; Yang Y; Liao MT; Zhong J; Li N; Liu TX; Wang G; Pan Y; Schal C; Li S;
Address:		"Guangdong Provincial Key Laboratory of Insect Developmental Biology and Applied Technology, Institute of Insect Science and Technology, School of Life Sciences, South China Normal University, Guangzhou, China. State Key Laboratory of Crop Stress Biology for Arid Areas, and Key Laboratory of Integrated Pest Management on the Loess Plateau of Ministry of Agriculture, Northwest A&F University, Yangling, China. Guangdong Laboratory for Lingnan Modern Agriculture, Guangzhou, China. Guangmeiyuan R&D Center, Guangdong Provincial Key Laboratory of Insect Developmental Biology and Applied Technology, South China Normal University, Meizhou, China. State Key Laboratory of Crop Stress Biology for Arid Areas, and Key Laboratory of Integrated Pest Management on the Loess Plateau of Ministry of Agriculture, Northwest A&F University, Yangling, China. yfan@nwsuaf.edu.cn. Laboratory of Insect Ecology and Molecular Biology, College of Plant Health and Medicine, Qingdao Agricultural University, Qingdao, China. Lingnan Guangdong Laboratory of Modern Agriculture, Genome Analysis Laboratory of the Ministry of Agriculture, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen, China. The Key Laboratory of Developmental Genes and Human Disease, School of Life Science and Technology, Southeast University, Nanjing, China. Department of Entomology and Plant Pathology, North Carolina State University, Raleigh, NC, USA. Guangdong Provincial Key Laboratory of Insect Developmental Biology and Applied Technology, Institute of Insect Science and Technology, School of Life Sciences, South China Normal University, Guangzhou, China. lisheng@scnu.edu.cn. Guangdong Laboratory for Lingnan Modern Agriculture, Guangzhou, China. lisheng@scnu.edu.cn. Guangmeiyuan R&D Center, Guangdong Provincial Key Laboratory of Insect Developmental Biology and Applied Technology, South China Normal University, Meizhou, China. lisheng@scnu.edu.cn"
Journal Title:		Nat Ecol Evol
Year:		2022
Volume:		20220704
Issue:		8
Page Number:		1180 - 1190
DOI:		10.1038/s41559-022-01808-w
ISSN/ISBN:		2397-334X (Electronic) 2397-334X (Linking)
Abstract:		"Sex differentiation and hormones are essential for the development of sexual signals in animals, and the regulation of sexual signals involves complex gene networks. However, it is unknown whether a core gene is able to connect the upstream regulators for controlling sexual signal outputs and behavioural consequences. Here, we identify a single gene that integrates both sex differentiation and hormone signalling with sexual attractiveness in an insect model. CYP4PC1 in the German cockroach, Blattella germanica, controls the rate-limiting step in producing female-specific contact sex pheromone (CSP) that stimulates male courtship. As revealed by behavioural, biochemical, molecular, genetic and bioinformatic approaches, in sexually mature females, CYP4PC1 expression and CSP production are coordinately induced by sex differentiation genes and juvenile hormone (JH) signalling. In adult males, direct inhibition of CYP4PC1 expression by doublesex(M) binding in gene promoter and lack of the gonadotropic hormone JH prevent CSP production, thus avoiding male-male attraction. By manipulating the upstream regulators, we show that wild-type males prefer to court cockroaches with higher CYP4PC1 expression and CSP production in a dose-dependent manner, regardless of their sex. These findings shed light on how sex-specific and high sexual attractiveness is conferred in insects"
Keywords:		Animals;Animals *Blattellidae/genetics Female *Juvenile Hormones/genetics/metabolism/pharmacology Male;
Notes:		"MedlineChen, Nan Liu, Yong-Jun Fan, Yong-Liang Pei, Xiao-Jin Yang, Yang Liao, Ming-Tao Zhong, Jiru Li, Na Liu, Tong-Xian Wang, Guirong Pan, Yufeng Schal, Coby Li, Sheng eng Research Support, Non-U.S. Gov't England 2022/07/06 Nat Ecol Evol. 2022 Aug; 6(8):1180-1190. doi: 10.1038/s41559-022-01808-w. Epub 2022 Jul 4"