| Title: | An online method for the analysis of volatile organic compounds in electronic cigarette aerosol based on proton transfer reaction mass spectrometry |
| Author(s): | Breiev K; Burseg KM; O'Connell G; Hartungen E; Biel SS; Cahours X; Colard S; Mark TD; Sulzer P; |
| Address: | "IONICON Analytik GmbH, Eduard-Bodem-Gasse 3, 6020, Innsbruck, Austria. Fontem Ventures B.V., Barbara Strozzilaan 101, 1083 HN, Amsterdam, The Netherlands. SEITA - Imperial Tobacco Group, 48 rue Danton, 45404, Fleury-les-Aubrais, France. Institut fur Ionenphysik und Angewandte Physik, Leopold-Franzens Universitat Innsbruck, Technikerstrasse 25/3, 6020, Innsbruck, Austria" |
| Journal Title: | Rapid Commun Mass Spectrom |
| ISSN/ISBN: | 1097-0231 (Electronic) 0951-4198 (Print) 0951-4198 (Linking) |
| Abstract: | "RATIONALE: Due to the recent rapid increase in electronic cigarette (e-cigarette) use worldwide, there is a strong scientific but also practical interest in analyzing e-cigarette aerosols. Most studies to date have used standardized but time-consuming offline technologies. Here a proof-of-concept for a fast online quantification setup based on proton transfer reaction mass spectrometry (PTR-MS) is presented. METHODS: The combination of a novel sampling interface with a time-of-flight PTR-MS instrument specially designed for three scenarios is introduced: (i) mainstream aerosol analysis (aerosol that the user inhales prior to exhalation), and analysis of exhaled breath following (ii) mouth-hold (no inhalation) and (iii) inhalation of e-cigarette aerosols. A double-stage dilution setup allows the various concentration ranges in these scenarios to be accessed. RESULTS: First, the instrument is calibrated for the three principal constituents of the e-cigarettes' liquids, namely propylene glycol, vegetable glycerol and nicotine. With the double-stage dilution the instrument's dynamic range was easily adapted to cover the concentration ranges obtained in the three scenarios: 20-1100 ppmv for the mainstream aerosol characterisation; 4-300 ppmv for the mouth-hold; and 2 ppbv to 20 ppmv for the inhalation experiment. CONCLUSIONS: It is demonstrated that the novel setup enables fast, high time resolution e-cigarette studies with online quantification. This enables the analysis and understanding of any puff-by-puff variations in e-cigarette aerosols. Large-scale studies involving a high number of volunteers will benefit from considerably higher sample throughput and shorter data processing times" |
| Notes: | "PubMed-not-MEDLINEBreiev, Kostiantyn Burseg, Kerstin M M O'Connell, Grant Hartungen, Eugen Biel, Stefan S Cahours, Xavier Colard, Stephane Mark, Tilmann D Sulzer, Philipp eng England 2016/02/13 Rapid Commun Mass Spectrom. 2016 Mar 30; 30(6):691-7. doi: 10.1002/rcm.7487" |
