« Previous AbstractUltrastructural Studies of the Effects of Allium sativum on Phytopathogenic Fungi in vitro    Next Abstract"[Studies in Val D'Agri (Basilicata Region, Southern Italy) improve knowledge and participation and require prevention interventions]" »

J Pharm Biomed Anal

Title:		Solid-phase microextraction coupled to gas chromatography-mass spectrometry followed by multivariate data analysis for the identification of volatile organic compounds as possible biomarkers in lung cancer tissues
Author(s):		Bianchi F; Riboni N; Carbognani P; Gnetti L; Dalcanale E; Ampollini L; Careri M;
Address:		"Dipartimento di Scienze Chimiche, della Vita e della Sostenibilita Ambientale, Universita di Parma, Parco Area delle Scienze 17/A, 43124 Parma, Italy. Electronic address: federica.bianchi@unipr.it. Dipartimento di Scienze Chimiche, della Vita e della Sostenibilita Ambientale, Universita di Parma, Parco Area delle Scienze 17/A, 43124 Parma, Italy. Dipartimento di Medicina e Chirurgia, Via Gramsci 14, Universita di Parma, 43121 Parma, Italy"
Journal Title:		J Pharm Biomed Anal
Year:		2017
Volume:		20170906
Issue:
Page Number:		329 - 333
DOI:		10.1016/j.jpba.2017.08.049
ISSN/ISBN:		1873-264X (Electronic) 0731-7085 (Linking)
Abstract:		"Solid-phase microextraction and gas chromatography-mass spectrometry followed by multivariate data analysis were used to analyze lung tissues from both healthy and carcinogenic patients. A total of 78 volatile compounds belonging to different chemical classes were identified, seven of which were able to discriminate between the two groups. Discriminant analysis allowed to correctly classify 98.3% of the cases. By using the leave-one-method, 100% of the cross-validated samples belonging to the 'tumor' group was correctly classified, whereas 2 cross-validated healthy samples out of 48 were erroneously allocated in the 'tumor' group. Achieved results suggest the need of further investigation to assess the role of the seven identified compounds as lung cancer biomarkers in breath analysis, thus allowing the development of low-cost diagnostic devices"
Keywords:		"Biomarkers, Tumor/*chemistry Breath Tests/methods Discriminant Analysis Gas Chromatography-Mass Spectrometry/methods Humans Lung Neoplasms/*chemistry Multivariate Analysis Solid Phase Microextraction/methods Volatile Organic Compounds/*chemistry Cancer bi;"
Notes:		"MedlineBianchi, Federica Riboni, Nicolo Carbognani, Paolo Gnetti, Letizia Dalcanale, Enrico Ampollini, Luca Careri, Maria eng England 2017/09/16 J Pharm Biomed Anal. 2017 Nov 30; 146:329-333. doi: 10.1016/j.jpba.2017.08.049. Epub 2017 Sep 6"