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Sci Rep

Title:		Pharmacological modulation of fish-induced depth selection in D. magna: the role of cholinergic and GABAergic signalling
Author(s):		Bedrossiantz J; Fuertes I; Raldua D; Barata C;
Address:		"Department of Environmental Chemistry, Institute of Environmental Assessment and Water Research, CSIC, Jordi Girobna 18, 08034, Barcelona, Spain. Department of Environmental Chemistry, Institute of Environmental Assessment and Water Research, CSIC, Jordi Girobna 18, 08034, Barcelona, Spain. cbmqam@cid.csic.es"
Journal Title:		Sci Rep
Year:		2021
Volume:		20210930
Issue:		1
Page Number:		19407 -
DOI:		10.1038/s41598-021-98886-w
ISSN/ISBN:		2045-2322 (Electronic) 2045-2322 (Linking)
Abstract:		"Animal behaviour is closely related to individual fitness, which allows animals to choose suitable mates or avoid predation. The central nervous system regulates many aspects of animal behaviour responses. Therefore, behavioural responses can be especially sensitive to compounds with a neurodevelopmental or neurofunctional mode of action. Phototactic behavioural changes against fish in the freshwater crustacean Daphnia magna have been the subject of many ecological investigations. The aim of this study was to identify which neurotransmitter systems modulate phototactic behaviour to fish kairomones. We used a positive phototactic D. magna clone (P(1)32,85) that shows marked negative phototactism after exposure to fish kairomones. Treatments included up to 16 known agonists and antagonists of the serotonergic, cholinergic, dopaminergic, histaminergic, glutamatergic and GABAergic systems. It was hypothesized that many neurological signalling pathways may modulate D. magna phototactic behaviour to fish kairomones. A new custom-designed device with vertically oriented chambers was used, and changes in the preferred areas (bottom, middle, and upper areas) were analysed using groups of animals after 24 h of exposure to the selected substance(s). The results indicated that agonists of the muscarinic acetylcholine and GABA(A) receptors and their equi-effective mixture ameliorated the negative phototactic response to fish kairomones, whereas antagonists and their mixtures increased the negative phototactism to fish kairomones. Interestingly, inhibition of the muscarinic acetylcholine receptor abolished positive phototaxis, thus inducing the phototactic response to fish kairomones. Analysis of the profile of neurotransmitters and their related metabolites showed that the D. magna behavioural responses induced by fish depend on changes in the levels of acetylcholine, dopamine and GABA"
Keywords:		"Animals Behavior, Animal/*drug effects Chemotaxis/*drug effects Cholinergic Agents/*pharmacology Daphnia/*metabolism GABA Agents/pharmacology Pheromones/*metabolism Phototaxis/*drug effects;"
Notes:		"MedlineBedrossiantz, Juliette Fuertes, Inmaculada Raldua, Demetrio Barata, Carlos eng Research Support, Non-U.S. Gov't England 2021/10/02 Sci Rep. 2021 Sep 30; 11(1):19407. doi: 10.1038/s41598-021-98886-w"