| Title: | Long-term ambient hydrocarbons exposure and incidence of ischemic stroke |
| Author(s): | Zhang HW; Kok VC; Chuang SC; Tseng CH; Lin CT; Li TC; Sung FC; Wen CP; Hsiung CA; Hsu CY; |
| Address: | "Ph.D. Program for Aging, China Medical University, Taichung, Taiwan. Department of Electrical and Computer Engineering, Institute of Electrical Control Engineering, National Chiao Tung University, Hsinchu, Taiwan. Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan. Disease Informatics Research Group, Asia University Taiwan, Taichung, Taiwan. Department of Internal Medicine, Kuang Tien General Hospital, Taichung, Taiwan. Department of Neurology, China Medical University Hospital, and School of Medicine, China Medical University, Taichung, Taiwan. Brain Research Center, National Chiao Tung University, Hsinchu, Taiwan. Centre for Artificial Intelligence School of Software, Faculty of Engineering & IT, University of Technology Sydney Broadway 2007, Sydney, New South Wales, Australia. Graduate Institute of Biostatistics, College of Public Health, China Medical University, Taichung, Taiwan. Department of Healthcare Administration, College of Health Science, Asia University, Taichung, Taiwan. Graduate Institute of Clinical Medical Science and School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan. Graduate Institute of Biomedical Science, China Medical University, Taichung, Taiwan" |
| DOI: | 10.1371/journal.pone.0225363 |
| ISSN/ISBN: | 1932-6203 (Electronic) 1932-6203 (Linking) |
| Abstract: | "Exposure to air pollutants is known to have adverse effects on human health; however, little is known about the association between hydrocarbons in air and an ischemic stroke (IS) event. We investigated whether long-term exposure to airborne hydrocarbons, including volatile organic compounds, increased IS risk. This retrospective cohort study included 283,666 people aged 40 years or older in Taiwan. Cox proportional hazards regression analysis was used to fit single- and multiple-pollutant models for two targeted pollutants, total hydrocarbons (THC) and nonmethane hydrocarbons (NMHC), and estimated the risk of IS. Before controlling for multiple pollutants, hazard ratios (HRs) of IS with 95% confidence intervals for the overall population were 2.69 (2.64-2.74) at 0.16-ppm increase in THC and 1.62 (1.59-1.66) at 0.11-ppm increase in NMHC. For the multiple-pollutant models controlling for PM2.5, the adjusted HR was 3.64 (3.56-3.72) for THC and 2.21 (2.16-2.26) for NMHC. Our findings suggest that long-term exposure to THC and NMHC may be a risk factor for IS development" |
| Keywords: | Adult Aged Air Pollutants/*adverse effects Brain Ischemia/*epidemiology Female Humans Hydrocarbons/*adverse effects Incidence Inhalation Exposure/adverse effects/*statistics & numerical data Male Middle Aged Stroke/*epidemiology Taiwan; |
| Notes: | "MedlineZhang, Han-Wei Kok, Victor C Chuang, Shu-Chun Tseng, Chun-Hung Lin, Chin-Teng Li, Tsai-Chung Sung, Fung-Chang Wen, Chi Pang Hsiung, Chao A Hsu, Chung Y eng 2019/12/05 PLoS One. 2019 Dec 4; 14(12):e0225363. doi: 10.1371/journal.pone.0225363. eCollection 2019" |
