| Title: | Estimation of the environmental effect of natural volatile organic compounds from Chamaecyparis obtusa and their effect on atopic dermatitis-like skin lesions in mice |
| Author(s): | Yang H; Ahn C; Choi IG; Choi WS; Park MJ; Lee SS; Choi DH; Jeung EB; |
| Address: | "Laboratory of Veterinary Biochemistry and Molecular Biology, College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk 361?ª╡763, Republic of Korea. Department of Forest Sciences, College of Agriculture and Life Sciences, Seoul National University, Seoul 151?ª╡921, Republic of Korea. Chromatography Laboratory, National Instrumentation Center for Environmental Management, Seoul National University, Seoul 151?ª╡921, Republic of Korea. Department of Forest Products, Division of Wood Chemistry and Microbiology, Korea Forest Research Institute, Seoul 130?ª╡712, Republic of Korea" |
| ISSN/ISBN: | 1791-3004 (Electronic) 1791-2997 (Linking) |
| Abstract: | "Aromatherapy has been suggested as an alternative therapeutic method for the treatment of atopic dermatitis (AD), eczema and other skin diseases. In the current study, the anti-atopic properties of the volatile organic compounds of Chamaecyparis obtusa (VOCCo) were examined to determine whether they are amenable for use as a pharmaceutical candidate. The alterations in histological features, serum IgE levels and mast cell infiltration following exposure to VOCCo were determined in a 2,4-dinitrochlorobenzene (DNCB)-induced AD-like mouse model. The results of these experiments demonstrated that VOCCo inhibited the development of AD-like skin lesions by reducing the serum IgE level and mast cell infiltration into the dermal and subcutaneous layers. This was supported by screening of immune cytokine mRNAs, including interleukin (IL)-1beta and IL-6 from the skin of DNCB-treated mice. The expression of IL-1beta and IL-6 in the skin lesions of mice was dose-dependently inhibited by treatment with VOCCo. Furthermore, treatment with VOCCo resulted in the recovery of histopathological features in AD-like skin lesions. These results suggest that VOCCo may have therapeutic and preventive effects for the development of AD" |
| Keywords: | "Animals Chamaecyparis/*chemistry/metabolism Dermatitis, Atopic/chemically induced/*pathology/therapy Dinitrochlorobenzene/toxicity Disease Models, Animal Gene Expression Regulation/drug effects Immunoglobulin E/blood Interleukin-1beta/genetics/metabolism;" |
| Notes: | "MedlineYang, Hyun Ahn, Changhwan Choi, In-Gyu Choi, Won-Sil Park, Mi-Jin Lee, Sung-Suk Choi, Don-Ha Jeung, Eui-Bae eng Research Support, Non-U.S. Gov't Greece 2015/03/12 Mol Med Rep. 2015 Jul; 12(1):345-50. doi: 10.3892/mmr.2015.3431. Epub 2015 Mar 5" |
