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Biol Reprod

Title:		Decline in male mouse pheromone with age
Author(s):		Wilson MC; Harrison DE;
Address:
Journal Title:		Biol Reprod
Year:		1983
Volume:		29
Issue:		1
Page Number:		81 - 86
DOI:		10.1095/biolreprod29.1.81
ISSN/ISBN:		0006-3363 (Print) 0006-3363 (Linking)
Abstract:		"An age-related decline in urinary-borne pheromone was found in male C57BL/6J mice aged from 2 to 30 months. Pheromone activity, estimated by bioassay, declined sharply after about 10 months of age. Two other strains of mice tested (DBA/2J and CBA/HT6J) also appeared to show an age-related decline in pheromone activity. Within each strain, however, pheromone activity was consistently similar to or higher than that of the C57BL/6J male mice. The DBA/2J and BALB/cWt strains appeared to be high pheromone producers, and the C57BL/6J and CBA/HT6J strains, low producers. This report is the first demonstration of a decline with age in male mouse pheromone activity. This decline appears to be synchronized with the well-defined loss of reproductive function in female mice"
Keywords:		"*Aging Animals Female Male Mice Mice, Inbred BALB C/*physiology Pheromones/*urine Reproduction Species Specificity;"
Notes:		"MedlineWilson, M C Harrison, D E eng AG 00594/AG/NIA NIH HHS/ AG 01755/AG/NIA NIH HHS/ Research Support, U.S. Gov't, P.H.S. 1983/08/01 Biol Reprod. 1983 Aug; 29(1):81-6. doi: 10.1095/biolreprod29.1.81"