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J Chromatogr B Analyt Technol Biomed Life Sci

Title:		Analysis of low molecular weight compounds by MALDI-FTICR-MS
Author(s):		Wang HY; Chu X; Zhao ZX; He XS; Guo YL;
Address:		"Shanghai Mass Spectrometry Center, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, PR China. haoyangwang@mail.sioc.ac.cn"
Journal Title:		J Chromatogr B Analyt Technol Biomed Life Sci
Year:		2011
Volume:		20110407
Issue:		17-18
Page Number:		1166 - 1179
DOI:		10.1016/j.jchromb.2011.03.037
ISSN/ISBN:		1873-376X (Electronic) 1570-0232 (Linking)
Abstract:		"This review focuses on recent applications of matrix-assisted laser desorption ionization-Fourier-transform ion cyclotron resonance mass spectrometry (MALDI-FTICR-MS) in qualitative and quantitative analysis of low molecular weight compounds. The scope of the work includes amino acids, small peptides, mono and oligosaccharides, lipids, metabolic compounds, small molecule phytochemicals from medicinal herbs and even the volatile organic compounds from tobacco. We discuss both direct analysis and analysis following derivatization. In addition we review sample preparation strategies to reduce interferences in the low m/z range and to improve sensitivities by derivatization with charge tags. We also present coupling of head space techniques with MALDI-FTICR-MS. Furthermore, omics analyses based on MALDI-FTICR-MS were also discussed, including proteomics, metabolomics and lipidomics, as well as the relative MS imaging for bio-active low molecular weight compounds. Finally, we discussed the investigations on dissociation/rearrangement processes of low molecular weight compounds by MALDI-FTICR-MS"
Keywords:		"Fourier Analysis Metabolomics/instrumentation/*methods Molecular Weight Proteomics/instrumentation/*methods Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization/instrumentation/*methods;"
Notes:		"MedlineWang, Hao-Yang Chu, Xu Zhao, Zhi-Xiong He, Xiao-Shuang Guo, Yin-Long eng Research Support, Non-U.S. Gov't Review Netherlands 2011/04/13 J Chromatogr B Analyt Technol Biomed Life Sci. 2011 May 15; 879(17-18):1166-79. doi: 10.1016/j.jchromb.2011.03.037. Epub 2011 Apr 7"