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Front Mol Biosci

Title:		Metabolic Biomarkers of Ageing in C57BL/6J Wild-Type and Flavin-Containing Monooxygenase 5 (FMO5)-Knockout Mice
Author(s):		Varshavi D; Scott FH; Varshavi D; Veeravalli S; Phillips IR; Veselkov K; Strittmatter N; Takats Z; Shephard EA; Everett JR;
Address:		"Medway Metabonomics Research Group, University of Greenwich, Chatham, United Kingdom. Institute of Structural and Molecular Biology, University College London, London, United Kingdom. School of Biological and Chemical Sciences, Queen Mary University of London, London, United Kingdom. Department of Surgery and Cancer, Faculty of Medicine, Imperial College, London, United Kingdom"
Journal Title:		Front Mol Biosci
Year:		2018
Volume:		20180409
Issue:
Page Number:		28 -
DOI:		10.3389/fmolb.2018.00028
ISSN/ISBN:		2296-889X (Print) 2296-889X (Electronic) 2296-889X (Linking)
Abstract:		"It was recently demonstrated in mice that knockout of the flavin-containing monooxygenase 5 gene, Fmo5, slows metabolic ageing via pleiotropic effects. We have now used an NMR-based metabonomics approach to study the effects of ageing directly on the metabolic profiles of urine and plasma from male, wild-type C57BL/6J and Fmo5(-/-) (FMO5 KO) mice back-crossed onto the C57BL/6J background. The aim of this study was to identify metabolic signatures that are associated with ageing in both these mouse lines and to characterize the age-related differences in the metabolite profiles between the FMO5 KO mice and their wild-type counterparts at equivalent time points. We identified a range of age-related biomarkers in both urine and plasma. Some metabolites, including urinary 6-hydroxy-6-methylheptan-3-one (6H6MH3O), a mouse sex pheromone, showed similar patterns of changes with age, regardless of genetic background. Others, however, were altered only in the FMO5 KO, or only in the wild-type mice, indicating the impact of genetic modifications on mouse ageing. Elevated concentrations of urinary taurine represent a distinctive, ageing-related change observed only in wild-type mice"
Keywords:		6-hydroxy-6-methyl-heptan-3-one C57bl/6j Fmo5 ko ageing metabolomics metabonomics plasma urine;
Notes:		"PubMed-not-MEDLINEVarshavi, Dorsa Scott, Flora H Varshavi, Dorna Veeravalli, Sunil Phillips, Ian R Veselkov, Kirill Strittmatter, Nicole Takats, Zoltan Shephard, Elizabeth A Everett, Jeremy R eng Switzerland 2018/04/25 Front Mol Biosci. 2018 Apr 9; 5:28. doi: 10.3389/fmolb.2018.00028. eCollection 2018"