| Title: | In vitro susceptibility of Brachyspira hyodysenteriae to organic acids and essential oil components |
| Author(s): | Vande Maele L; Heyndrickx M; Maes D; De Pauw N; Mahu M; Verlinden M; Haesebrouck F; Martel A; Pasmans F; Boyen F; |
| Address: | "Department of Pathology, Bacteriology and Poultry Diseases, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820, Merelbeke, Belgium" |
| ISSN/ISBN: | 1347-7439 (Electronic) 0916-7250 (Print) 0916-7250 (Linking) |
| Abstract: | "The antibacterial potential of organic acids and essential oil components against Brachyspira hyodysenteriae, the causative pathogen of swine dysentery, was evaluated. Minimum inhibitory concentrations (MIC) of 15 compounds were determined at pH 7.2 and pH 6.0, using a broth microdilution assay. In addition, possible synergism was determined. MIC values for the three tested strains were similar. For organic acids, MIC values at pH 6.0 were lower than at pH 7.2. B. hyodysenteriae was most sensitive to cinnamaldehyde and lauric acid, with MIC values <1.5 mM. Most antibacterial effects of binary combinations were additive, however, for thymol and carvacrol, synergism could be observed. In vitro results demonstrate the antibacterial action of certain essential oil components and organic acids against B. hyodysenteriae" |
| Keywords: | "Acids/*pharmacology Anti-Bacterial Agents/*pharmacology Brachyspira hyodysenteriae/*drug effects Microbial Sensitivity Tests Oils, Volatile/*pharmacology;" |
| Notes: | "MedlineVande Maele, Lien Heyndrickx, Marc Maes, Dominiek De Pauw, Nele Mahu, Maxime Verlinden, Marc Haesebrouck, Freddy Martel, An Pasmans, Frank Boyen, Filip eng Research Support, Non-U.S. Gov't Japan 2015/09/16 J Vet Med Sci. 2016 Feb; 78(2):325-8. doi: 10.1292/jvms.15-0341. Epub 2015 Sep 14" |
