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Chem Senses

Title:		Green spotted puffers detect a nontoxic TTX analog odor using crypt olfactory sensory neurons
Author(s):		Suzuki T; Nakahigashi R; Adachi M; Nishikawa T; Abe H;
Address:		"Laboratory of Fish Biology, Department of Animal Sciences, Graduate School of Bioagricultural Sciences, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, Aichi 464-8601, Japan. Laboratory of Organic Chemistry, Department of Applied Biosciences, Graduate School of Bioagricultural Sciences, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, Aichi 464-8601, Japan"
Journal Title:		Chem Senses
Year:		2022
Volume:		47
Issue:
Page Number:		-
DOI:		10.1093/chemse/bjac011
ISSN/ISBN:		1464-3553 (Electronic) 0379-864X (Linking)
Abstract:		"Toxic puffers accumulate their defense substance (tetrodotoxin; TTX) through the food chain. Although the previous study suggests that 5,6,11-trideoxyTTX, a nontoxic TTX analog detected simultaneously with TTX in toxic puffers or their prey, acts as an olfactory chemoattractant for grass puffers, it is unclear whether toxic puffers are commonly attracted to 5,6,11-trideoxyTTX, and which types of olfactory sensory neurons (OSNs) detect 5,6,11-trideoxyTTX. Here, we demonstrated that green spotted puffer, a phylogenetically distant species from the grass puffer, is attracted to 5,6,11-trideoxyTTX. 5,6,11-TrideoxyTTX administration made green spotted puffers stay longer at the administered site, whereas a food odor (l-Arg) made them actively swim throughout the aquarium. Attractive responses were not observed when TTX or its vehicle was administered, nor when 5,6,11-trideoxyTTX was administered to anosmic fish. Furthermore, double immunohistochemistry with activity marker and crypt OSN marker antibodies labeled oval cells with apical invagination on the olfactory epithelium surface treated with 5,6,11-trideoxyTTX. These results suggest that 5,6,11-trideoxyTTX acts as an olfactory chemoattractant detected by crypt OSNs, and attraction to 5,6,11-trideoxyTTX odor appears to be a trait shared by toxic puffers for social communication or effective toxification"
Keywords:		Animals Chemotactic Factors Odorants Olfactory Mucosa *Olfactory Receptor Neurons *Tetraodontiformes Tetrodotoxin/chemistry/pharmacology activity labeling attractive behavior chemical communication chemoattractant pheromone toxification;
Notes:		"MedlineSuzuki, Takehisa Nakahigashi, Ryota Adachi, Masaatsu Nishikawa, Toshio Abe, Hideki eng Research Support, Non-U.S. Gov't England 2022/05/18 Chem Senses. 2022 Jan 1; 47:bjac011. doi: 10.1093/chemse/bjac011"