| Title: | Biotechnological applications of quorum sensing inhibition as novel therapeutic strategies for multidrug resistant pathogens |
| Author(s): | Shaaban M; Elgaml A; Habib EE; |
| Address: | "Department of Pharmaceutics and Pharmaceutical Technology, College of Pharmacy, Taibah University, Al Madinah Al Munawwarah, 30078, Saudi Arabia; Department of Microbiology and Immunology, Faculty of Pharmacy, Mansoura University, 35516, Egypt. Department of Microbiology and Immunology, Faculty of Pharmacy, Mansoura University, 35516, Egypt; Department of Microbiology, Faculty of Pharmacy, Horus University, New Damietta, 34517, Egypt. Department of Pharmaceutics and Pharmaceutical Technology, College of Pharmacy, Taibah University, Al Madinah Al Munawwarah, 30078, Saudi Arabia; Department of Microbiology and Immunology, Faculty of Pharmacy, Mansoura University, 35516, Egypt. Electronic address: sayedhabib2011@yahoo.com" |
| DOI: | 10.1016/j.micpath.2018.11.043 |
| ISSN/ISBN: | 1096-1208 (Electronic) 0882-4010 (Linking) |
| Abstract: | "High incidence of antibiotic resistance among bacterial clinical isolates necessitates the discovery of new targets for inhibition of microbial pathogenicity, without stimulation of microbial resistance. This could be achieved by targeting virulence determinants, which cause host damage and disease. Many pathogenic bacteria elaborate signaling molecules for cellular communication. This signaling system is named quorum sensing system (QS), and it is contingent on the bacterial population density and mediated by signal molecules called pheromones or autoinducers (AIs). Bacteria utilize QS to regulate activities and behaviors including competence, conjugation, symbiosis, virulence, motility, sporulation, antibiotic production, and biofilm formation. Hence, targeting bacterial communicating signals and suppression of QS exhibit a fundamental approach for competing microbial communication. In this review, we illustrate the common up to date approaches to utilize QS circuits in pathogenic bacteria, including Vibrio fischeri, Pseudomonas aeruginosa, Escherichia coli and Acinetobacter baumannii, as novel therapeutic targets" |
| Keywords: | "Adaptation, Physiological/*drug effects Animals Anti-Bacterial Agents/isolation & purification/*pharmacology/therapeutic use Disease Models, Animal *Drug Resistance, Multiple, Bacterial Gram-Negative Bacteria/*drug effects/*physiology Gram-Negative Bacter;" |
| Notes: | "MedlineShaaban, Mona Elgaml, Abdelaziz Habib, El-Sayed E eng Review England 2018/12/07 Microb Pathog. 2019 Feb; 127:138-143. doi: 10.1016/j.micpath.2018.11.043. Epub 2018 Nov 29" |
