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Brain Res

Title:		Concurrent androgenic stimulation of the ventral tegmental area and medial preoptic area: synergistic effects on male-typical reproductive behaviors in house mice
Author(s):		Sipos ML; Nyby JG;
Address:		"Department of Biological Sciences, Lehigh University, Bethlehem, PA 18015, USA"
Journal Title:		Brain Res
Year:		1996
Volume:		729
Issue:		1
Page Number:		29 - 44
DOI:
ISSN/ISBN:		0006-8993 (Print) 0006-8993 (Linking)
Abstract:		"Cannulae containing testosterone proprionate (T) were bilaterally implanted into the medial preoptic area (MPO), the ventral tegmental area (VTA), or both areas concurrently (MPO/VTA) of castrated male house mice. A fourth group of castrates in which the intracranial implants missed their targets (MIMP) served as controls. In addition, other castrates were implanted subcutaneously with empty silastic capsules (BSIL) or silastic capsules containing T (TSIL). All subjects were examined for the following male-typical behaviors: mounting, attraction to female urine, ultrasonic mating vocalizations and urinary scent marking. In addition, the males were tested for activity levels to insure that they were not motorically impaired. In general, TSIL implants restored all male-typical behaviors to normal levels, whereas BSIL and MIMP implants were generally ineffective. Similar to previous findings, MPO implants alone completely restored ultrasonic vocalizations, partially restored urine marking, and had little or no effect upon mounting or urine preference. In contrast, VTA implants alone were ineffective at restoring any of these male-typical behaviors. However, the combined MPO/VTA implants were the most effective in restoring male-typical behaviors. In fact, a synergism between concurrent hormone action in the MPO and VTA was seen for mounting and urine preference. We interpret these data to indicate that androgen may act simultaneously in the MPO and VTA for more complete expression of some male-typical reproductive behaviors"
Keywords:		"Animals Brain Mapping/*methods Drug Implants Female Male Mice Mice, Inbred C57BL Motor Activity/drug effects Preoptic Area/*drug effects Sex Attractants Sexual Behavior, Animal/*drug effects Stimulation, Chemical Testis/physiology Testosterone/*pharmacolo;"
Notes:		"MedlineSipos, M L Nyby, J G eng Netherlands 1996/08/05 Brain Res. 1996 Aug 5; 729(1):29-44"