| Title: | Aqua/Mechanochemical Mediated Synthesis of Novel Spiro [Indole-Pyrrolidine] Derivatives |
| Author(s): | Salami SA; Smith VJ; Krause RWM; |
| Address: | "Department of Chemistry, Rhodes University, Grahamstown 6140, South Africa" |
| ISSN/ISBN: | 1422-0067 (Electronic) 1422-0067 (Linking) |
| Abstract: | "Spirocyclic scaffolds are found in many pharmacologically active natural and synthetic compounds. From time to time, efforts have been made to develop new or better processes for the synthesis of spirocyclic compounds. Spiro [Indole-pyrrolidine] Derivatives are readily synthesized in high to excellent yields by the Michael condensation of 3-dicyanomethylene-2H-indol-2-ones (produced via the Knoevenagel condensation of indole-2,3-dione with malononitrile) with isothiocyanate derivatives under aqueous and mechanochemical conditions. The advantages of this protocol are that the reactions are solvent-free, occur at ambient temperature, require short reaction times, have experimental simplicity, and produce excellent yields. These environmentally friendly reaction media are useful alternatives to volatile organic solvents" |
| Keywords: | "*Indoles/chemistry Pyrrolidines *Spiro Compounds 3-dicyanomethylene-2H-indole-2-ones aqueous media indole-2, 3-diones isothiocyanates mechanochemistry spiro [indole-pyrrolidine;" |
| Notes: | "MedlineSalami, Sodeeq Aderotimi Smith, Vincent J Krause, Rui Werner Macedo eng 116109/National Research Foundation/ Switzerland 2023/02/12 Int J Mol Sci. 2023 Jan 24; 24(3):2307. doi: 10.3390/ijms24032307" |
