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Semin Cell Dev Biol

Title:		Down regulation of yeast G protein-coupled receptors
Author(s):		Riezman H;
Address:		"Biozentrum of the University of Basel, Switzerland"
Journal Title:		Semin Cell Dev Biol
Year:		1998
Volume:		9
Issue:		2
Page Number:		129 - 134
DOI:		10.1006/scdb.1997.0217
ISSN/ISBN:		1084-9521 (Print) 1084-9521 (Linking)
Abstract:		"G protein-coupled receptors are essential components of the pheromone signaling pathway in Saccharomyces cerevisiae. When ligands bind to these receptors, their down regulation is stimulated. The sequence of events in this process is proposed to be the following: ligand-induced conformational change, receptor hyperphosphorylation and ubiquitination, internalization by an actin-dependent mechanism and subsequent delivery through at least two endocytic intermediates to the vacuole where the receptors are degraded"
Keywords:		"Adaptation, Physiological Animals *Down-Regulation GTP-Binding Proteins/*physiology Humans Protein Conformation Receptors, Cell Surface/*physiology Ubiquitins/physiology Yeasts/*physiology;"
Notes:		"MedlineRiezman, H eng Research Support, Non-U.S. Gov't Review England 1998/05/26 Semin Cell Dev Biol. 1998 Apr; 9(2):129-34. doi: 10.1006/scdb.1997.0217"