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J Chromatogr Sci

Title:		Factors that influence the determination of residual solvents in pharmaceuticals by automated static headspace sampling coupled to capillary GC-MS
Author(s):		Mulligan KJ; McCauley H;
Address:		"National Forensic Chemistry Center, U.S. Food and Drug Administration, Cincinnati, Ohio 45202"
Journal Title:		J Chromatogr Sci
Year:		1995
Volume:		33
Issue:		1
Page Number:		49 - 54
DOI:		10.1093/chromsci/33.1.49
ISSN/ISBN:		0021-9665 (Print) 0021-9665 (Linking)
Abstract:		"The impact of several experimental parameters on static headspace sampling for volatile impurities is discussed. Figures of merit are provided for some common organic solvents dissolved in dimethylacetamide. The performance is compound specific, but in the best case, detectability is about 0.2 mg/L with the mass spectrometer operating in the scanning mode. Sensitivity improves by about a factor of 50 when single ion monitoring is used. Linearity extends for about 4 orders of magnitude. This system is used to determine acetone as a residual solvent in the sulfonamide antibiotic, sulfamethazine, at levels of 1 to 15 mg/kg with precision of 3 to 5%"
Keywords:		Acetamides/analysis Acetone/analysis Gas Chromatography-Mass Spectrometry/*methods Solvents/*analysis Sulfamethazine/*chemistry Temperature Water/analysis;
Notes:		"MedlineMulligan, K J McCauley, H eng 1995/01/01 J Chromatogr Sci. 1995 Jan; 33(1):49-54. doi: 10.1093/chromsci/33.1.49"