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Biosci Biotechnol Biochem

Title:		Determination of the stereochemistry of (-)-koninginin A by an X-ray analysis of its synthetic sample
Author(s):		Mori K; Bando M; Abe K;
Address:		"Insect Pheromone and Traps Division, Fuji Flavor Co. Ltd., Hamura-City, Tokyo, Japan"
Journal Title:		Biosci Biotechnol Biochem
Year:		2002
Volume:		66
Issue:		8
Page Number:		1779 - 1781
DOI:		10.1271/bbb.66.1779
ISSN/ISBN:		0916-8451 (Print) 0916-8451 (Linking)
Abstract:		"The absolute configuration of (-)-koninginin A [10-hexyl-11, 12-dioxatricyclo[7.2. 1.0<1 ,6>]dodecane-2,5-diol (1)], the antibiotic metabolite of Trichoderma koningii and T. harzianum, was determined as 1S, 2R, 5S, 6S, 9S, 10S by an X-ray crystallographic analysis of its synthetic sample coupled with the established stereochemical outcome of Sharpless asymmetric dihydroxylation used as the key reaction to prepare intermediate 4"
Keywords:		"Benzoxepins/*chemistry Crystallography, X-Ray Heterocyclic Compounds, 3-Ring/*chemistry Molecular Conformation Stereoisomerism Trichoderma/chemistry;"
Notes:		"MedlineMori, Kenji Bando, Masahiko Abe, Kaoru eng England 2002/10/02 Biosci Biotechnol Biochem. 2002 Aug; 66(8):1779-81. doi: 10.1271/bbb.66.1779"