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Ind Health

Title:		Ocular irritation from product of pesticide degradation among workers in a seed warehouse
Author(s):		Matsukawa T; Yokoyama K; Itoh H;
Address:		"Department of Epidemiology and Environmental Health, Juntendo University Faculty of Medicine, Japan"
Journal Title:		Ind Health
Year:		2015
Volume:		20141017
Issue:		1
Page Number:		95 - 99
DOI:		10.2486/indhealth.2014-0147
ISSN/ISBN:		1880-8026 (Electronic) 0019-8366 (Print) 0019-8366 (Linking)
Abstract:		"Four workers at a seed supply warehouse in Chiba Prefecture, Japan, complained of ocular irritation on the job. Pesticide-coated seeds were stored in the warehouse but no significant amount of pesticide was detected in the air inside the warehouse. To identify the cause of the ocular irritation and to determine an appropriate solution to the problem, the authors used thermal desorption gas chromatography-mass spectrometry to analyze the profiles of volatile organic compounds (VOCs) in the air of the two warehouses at the site-warehouse A, where the four workers experienced ocular irritation, and warehouse B, where no workers experienced ocular irritation. Comparing the profiles of VOCs in these warehouses indicated that n-butyl isocyanate, a hydrolyzed product of the fungicide benomyl, was the cause of the workers' ocular irritation. n-Butyl isocyanate is known to be a contact irritant and if the benomyl-coated seeds were not properly dried before storage in the warehouse n-butyl isocyanate would have been produced. The results of the study suggest that more attention should be paid both to the pesticide itself and to the products of pesticide degradation. In this study, n-butyl isocyanate was identified as a product of pesticide degradation and a causative chemical affecting occupational health"
Keywords:		"*Agriculture Air Pollutants, Occupational/analysis/toxicity Benomyl/chemistry Eye Diseases/*chemically induced Fungicides, Industrial/chemistry Isocyanates/analysis/*toxicity Occupational Exposure/*adverse effects *Seeds;"
Notes:		"MedlineMatsukawa, Takehisa Yokoyama, Kazuhito Itoh, Hiroaki eng Japan 2014/10/21 Ind Health. 2015; 53(1):95-9. doi: 10.2486/indhealth.2014-0147. Epub 2014 Oct 17"