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Talanta

Title:		Doping-assisted low-pressure photoionization mass spectrometry for the real-time detection of lung cancer-related volatile organic compounds
Author(s):		Li Z; Xu C; Shu J; Yang B; Zou Y;
Address:		"State Key Joint Laboratory of Environment Simulation and Pollution Control, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China; University of Chinese Academy of Sciences, Beijing, China. State Key Joint Laboratory of Environment Simulation and Pollution Control, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China; University of Chinese Academy of Sciences, Beijing, China. Electronic address: jshu@rcees.ac.cn"
Journal Title:		Talanta
Year:		2017
Volume:		20161219
Issue:
Page Number:		98 - 106
DOI:		10.1016/j.talanta.2016.12.039
ISSN/ISBN:		1873-3573 (Electronic) 0039-9140 (Linking)
Abstract:		"Real-time detection of lung cancer-related volatile organic compounds (VOCs) is a promising, non-intrusive technique for lung cancer (LC) prescreening. In this study, a novel method was designed to enhance the detection selectivity and sensitivity of LC-related polar VOCs by dichloromethane (CH(2)Cl(2)) doping-assisted low-pressure photoionization mass spectrometry (LPPI-MS). Compared with conventional LPPI-MS, CH(2)Cl(2) doping-assisted LPPI-MS boosted the peak intensities of n-propanol, n-pentanal, acetone, and butyl acetate in nitrogen specifically by 53, 18, 16, and 43 times, respectively. The signal intensities of their daughter ions were inhibited or reduced. At relative humidity (RH) of 20%, the sensitivities of n-propanol, n-pentanal, acetone, and butyl acetate detection ranged from 116 to 452 counts/ppbv with a detection time of 10s and R(2) >0.99 for the linear calibration curves. The method was also applicable under higher RH levels of 50% and 90%. Breath samples obtained from 10 volunteers and spiked samples were investigated. Eight-fold enhancements in the signal intensities of polar VOCs were observed in the normal and spiked samples. These preliminary results demonstrate the efficacy of the dichloromethane doping-assisted LPPI technique for the detection of LC-related polar VOCs. Further studies are indispensible to illustrating the detailed mechanism and applying the technique to breath diagnosis"
Keywords:		Breath Tests/*methods Humans Lung/*metabolism Lung Neoplasms/*metabolism Mass Spectrometry/*methods Volatile Organic Compounds/*analysis Dopant Low pressure photoionization mass spectrometry Lung cancer Polar VOC;
Notes:		"MedlineLi, Zhen Xu, Ce Shu, Jinian Yang, Bo Zou, Yao eng Netherlands 2017/02/06 Talanta. 2017 Apr 1; 165:98-106. doi: 10.1016/j.talanta.2016.12.039. Epub 2016 Dec 19"