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Infect Immun

Title:		Hemolysin of Streptococcus faecalis subspecies zymogenes contributes to virulence in mice
Author(s):		Ike Y; Hashimoto H; Clewell DB;
Address:
Journal Title:		Infect Immun
Year:		1984
Volume:		45
Issue:		2
Page Number:		528 - 530
DOI:		10.1128/iai.45.2.528-530.1984
ISSN/ISBN:		0019-9567 (Print) 1098-5522 (Electronic) 0019-9567 (Linking)
Abstract:		The conjugative plasmid pAD1 (56.7 kilobases) in Streptococcus faecalis confers hemolysin-bacteriocin (Hly-Bcn) expression and a mating response to the sex pheromone cAD1 excreted by recipient cells. We examined the contribution of hemolysin to pathogenicity in intraperitoneally infected mice by using Tn916 and Tn917 insertion mutants altered in hemolysin expression. Strains exhibiting the normal hemolysin phenotype were significantly more virulent than the nonhemolytic insertion mutants. A mutant plasmid with an increased copy number which gave rise to a larger-than-normal zone of hemolysis on blood agar rendered host strains more virulent than the wild-type streptococci in mice
Keywords:		"Animals DNA Transposable Elements DNA, Recombinant Enterococcus faecalis/genetics/*pathogenicity Hemolysin Proteins/genetics Mice Plasmids;"
Notes:		"MedlineIke, Y Hashimoto, H Clewell, D B eng 1984/08/01 Infect Immun. 1984 Aug; 45(2):528-30. doi: 10.1128/iai.45.2.528-530.1984"