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Insect Mol Biol

Title:		"Identification of an E-box DNA binding protein, activated protein 4, and its function in regulating the expression of the gene encoding diapause hormone and pheromone biosynthesis-activating neuropeptide in Helicoverpa armigera"
Author(s):		Hu CH; Hong B; Xu WH;
Address:		"State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-Sen (Zhongshan) University, Guangzhou, China"
Journal Title:		Insect Mol Biol
Year:		2010
Volume:		20100118
Issue:		2
Page Number:		243 - 252
DOI:		10.1111/j.1365-2583.2009.00983.x
ISSN/ISBN:		1365-2583 (Electronic) 0962-1075 (Linking)
Abstract:		"Activated protein 4 (AP-4), an E-box DNA-binding protein, was cloned from the cotton bollworm, Helicoverpa armigera (Har). The expression of Har-AP-4 mRNA and the protein that it encodes are significantly higher in nondiapause pupae than in diapause pupae. In vitro-translated Har-AP-4 can bind specifically to the E-box motif on the promoter of the diapause hormone and pheromone biosynthesis-activating neuropeptide (DH-PBAN). Har-AP-4, fused with the green fluorescent protein (GFP), is localized to the nucleus, and overexpression of Har-AP-4 can significantly activate the promoter of the DH-PBAN gene that is involved in nondiapause pupal development in H. armigera. These results suggest that Har-AP-4, which binds to the promoter of DH-PBAN, may play a role in regulating pupal development in H. armigera"
Keywords:		"Amino Acid Sequence Animals Animals, Genetically Modified Base Sequence Cloning, Molecular DNA/genetics/metabolism DNA-Binding Proteins/genetics/*metabolism E-Box Elements Genes, Insect Insect Hormones/*genetics Insect Proteins/genetics/*metabolism Lepido;"
Notes:		"MedlineHu, C-H Hong, B Xu, W-H eng Research Support, Non-U.S. Gov't England 2010/01/22 Insect Mol Biol. 2010 Apr; 19(2):243-52. doi: 10.1111/j.1365-2583.2009.00983.x. Epub 2010 Jan 18"