| Title: | A missense polymorphism in the putative pheromone receptor gene VN1R1 is associated with sociosexual behavior |
| Author(s): | Henningsson S; Hovey D; Vass K; Walum H; Sandnabba K; Santtila P; Jern P; Westberg L; |
| Address: | "Department of Pharmacology, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. Center for Translational Social Neuroscience, Emory University, Atlanta, GA, USA. Silvio O. Conte Center for Oxytocin and Social Cognition, Center for Translational Social Neuroscience, Atlanta, GA, USA. Yerkes National Primate Research Center, Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA, USA. Department of Psychology, Faculty of Arts, Psychology and Theology, Abo Akademi University, Abo, Finland" |
| ISSN/ISBN: | 2158-3188 (Electronic) 2158-3188 (Linking) |
| Abstract: | "Pheromones regulate social and reproductive behavior in most mammalian species. These effects are mediated by the vomeronasal and main olfactory systems. Effects of putative pheromones on human neuroendocrine activity, brain activity and attractiveness ratings suggest that humans may communicate via similar chemosignaling. Here we studied two samples of younger and older individuals, respectively, with respect to one nonsynonymous polymorphism in the gene encoding the human vomeronasal type-1 receptor 1, VN1R1, and one nonsynonymous polymorphism in the gene encoding the olfactory receptor OR7D4. Participants in both samples had self-reported their sociosexual behavior using the sociosexual orientation inventory, including questions regarding lifetime number of one-night stands, number of partners last year and expected number of partners the coming 5 years. In women, there was a significant association between the VN1R1 polymorphism and sociosexual behavior in both samples, driven specifically by the question regarding one-night stands. Our results support the hypothesis that human social interaction is modulated by communication via chemosignaling" |
| Keywords: | "Adult Chemotactic Factors/*genetics Female Genotyping Techniques Humans Male Olfactory Bulb/physiology Olfactory Mucosa/*cytology/metabolism/physiology Pheromones, Human/physiology Polymorphism, Single Nucleotide/*genetics Receptors, Odorant/genetics Rece;neuroscience;" |
| Notes: | "MedlineHenningsson, S Hovey, D Vass, K Walum, H Sandnabba, K Santtila, P Jern, P Westberg, L eng Research Support, Non-U.S. Gov't 2017/04/26 Transl Psychiatry. 2017 Apr 25; 7(4):e1102. doi: 10.1038/tp.2017.70" |
