| Title: | The little difference: in vivo analysis of pheromone discrimination in Schizophyllum commune |
| Address: | "Friedrich-Schiller-University, Institute of Microbiology, Winzerlaer Strasse 10, 07745, Jena, Germany" |
| DOI: | 10.1007/s00294-002-0353-4 |
| ISSN/ISBN: | 0172-8083 (Print) 0172-8083 (Linking) |
| Abstract: | "The B mating type of Schizophyllum commune is defined by a multi-specific pheromone/receptor system. The interaction of pheromone receptors and their ligands, encoded by the Balpha locus, triggers sexual development. The receptors belong to the family of G protein-coupled seven-transmembrane-domain receptors, while the ligands are small lipopeptide pheromones. A productive interaction is only possible between molecules derived from different specificities. There is no induction of sexual development by pheromones of self-specificity. Since there are nine versions of different specificity for pheromones and receptors in Balpha, this system can be used to study multi-ligand discrimination. We investigated pheromone discrimination using chimeric receptor molecules and the influence of single point mutations on activation profiles of the receptor" |
| Keywords: | "Base Sequence Chemoreceptor Cells/chemistry/*physiology Crosses, Genetic DNA Primers Gene Expression Regulation, Fungal Genes, Fungal Genes, Mating Type, Fungal Mutagenesis Phenotype Pheromones/*physiology Protein Conformation Recombinant Fusion Proteins/;" |
| Notes: | "MedlineGola, Susanne Kothe, Erika eng Research Support, Non-U.S. Gov't 2003/02/18 Curr Genet. 2003 Feb; 42(5):276-83. doi: 10.1007/s00294-002-0353-4. Epub 2002 Dec 12" |
