| Title: | "Metal accumulation and morphofunctional damage in coelomocytes of earthworm collected from industrially contaminated soil of Kolkata, India" |
| Author(s): | Gautam A; Mukherjee S; Manna S; Banerjee P; Manna S; Ghosh AR; Ray M; Ray S; |
| Address: | "Aquatic Toxicology Laboratory, Department of Zoology, University of Calcutta, 35, Ballygunge Circular Road, Kolkata 700019, West Bengal, India. Aquatic Toxicology Laboratory, Department of Zoology, University of Calcutta, 35, Ballygunge Circular Road, Kolkata 700019, West Bengal, India; Department of Zoology, Brahmananda Keshab Chandra College, 111/2, Barrackpore Trunk Road, Kolkata 700108, West Bengal, India. Semiochemicals and Lipid Laboratory, Department of Life Science, Presidency University, 86/1, College Street, Kolkata 700073, West Bengal, India. Department of Environmental Science, University of Burdwan, Golapbag, Bardhaman 713104, West Bengal, India. Aquatic Toxicology Laboratory, Department of Zoology, University of Calcutta, 35, Ballygunge Circular Road, Kolkata 700019, West Bengal, India. Electronic address: raysnailmail@rediffmail.com" |
| Journal Title: | Comp Biochem Physiol C Toxicol Pharmacol |
| DOI: | 10.1016/j.cbpc.2022.109299 |
| ISSN/ISBN: | 1532-0456 (Print) 1532-0456 (Linking) |
| Abstract: | "The current study is aimed to assess the ecotoxicological effects of toxic metals and seasonal shift of the physicochemical characteristics of soil in an endogeic earthworm Metaphire posthuma of industrially contaminated soil of Calcutta leather complex. The accumulation of cadmium, chromium, lead and mercury was quantitated in whole earthworms and coelomocytes. The accumulation of metals was derived to be high in the coelomocytes than whole earthworms. Morphofunctional shift in coelomocytes indicated a high level of metal toxicity in soil inhabitants. The shift in differential coelomocyte count and cellular damage including intense cytoplasmic vacuolation and membrane blebbing of coelomocytes of M. posthuma of contaminated soil were suggestive to a state of immunocompromisation in the same species. Shift in the generation of nitric oxide and activity of inducible nitric oxide synthase indicated a possible immunosuppression in earthworm. Depletion in the acetylcholinesterase activity of coelomocytes indicated neurotoxicity of metals leached from the dumped wastes in Calcutta leather complex. Integrated biomarker response based analysis was carried out to assess the biomarker potential of experimental endpoints of M. posthuma to monitor metal toxicity in soil" |
| Keywords: | Acetylcholinesterase Animals Biomarkers India *Metals/analysis/toxicity *Oligochaeta *Soil Pollutants/analysis/toxicity Bioaccumulation factor Inducible nitric oxide synthase Metaphire posthuma Principal component analysis; |
| Notes: | "MedlineGautam, Arunodaya Mukherjee, Soumalya Manna, Sumit Banerjee, Pallab Manna, Sourav Ghosh, Apurba Ratan Ray, Mitali Ray, Sajal eng 2022/02/20 Comp Biochem Physiol C Toxicol Pharmacol. 2022 Jun; 256:109299. doi: 10.1016/j.cbpc.2022.109299. Epub 2022 Feb 17" |
