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Mol Gen Genet

Title:		The DAC2/FUS3 protein kinase is not essential for transcriptional activation of the mating pheromone response pathway in Saccharomyces cerevisiae
Author(s):		Fujimura HA;
Address:		"Laboratory for Molecular Biology, Hoechst Japan Limited, Kawagoe"
Journal Title:		Mol Gen Genet
Year:		1992
Volume:		235
Issue:		2-Mar
Page Number:		450 - 452
DOI:		10.1007/BF00279392
ISSN/ISBN:		0026-8925 (Print) 0026-8925 (Linking)
Abstract:		"The DAC2/FUS3 gene of Saccharomyces cerevisiae, which encodes a CDC28/cdc2-related protein kinase, is essential both for the arrest of cell division induced by mating pheromones and for cell fusion during conjugation. To elucidate the role of the DAC2 gene product in the pheromone response pathway, I determined the nucleotide sequence of the DAC2 gene and characterized two types of deletion mutants of the DAC2 gene. Here, I show that the DAC2 gene is identical to the FUS3 gene and that dac2/fus3 deletion mutants respond to mating pheromones by activating transcription. Therefore, the DAC2/FUS3 gene is not essential for transcriptional activation in the pheromone response pathway. The DAC2/FUS3 protein kinase has a positive role in cell fusion during sexual conjugation"
Keywords:		"Amino Acid Sequence Base Sequence CDC2-CDC28 Kinases Cell Division Conjugation, Genetic Crosses, Genetic Gene Deletion *Genes, Fungal Genotype Molecular Sequence Data Pheromones/*physiology Protein Kinases/*genetics/metabolism Protein Serine-Threonine Kin;"
Notes:		"MedlineFujimura, H A eng Germany 1992/11/01 Mol Gen Genet. 1992 Nov; 235(2-3):450-2. doi: 10.1007/BF00279392"