| Title: | Field induced fragmentation spectra from reactive stage-tandem differential mobility spectrometry |
| Author(s): | Fowler PE; Pilgrim JZ; Lee G; Eiceman GA; |
| Address: | "Department of Chemistry and Biochemistry, New Mexico State University, Las Cruces, NM 88003, USA.. geiceman@nmsu.edu" |
| ISSN/ISBN: | 1364-5528 (Electronic) 0003-2654 (Linking) |
| Abstract: | "A planar tandem differential mobility spectrometer was integrated with a middle reactive stage to fragment ions which were mobility selected in a first analyzer stage using characteristic compensation and separation fields. Fragmentation occurred in air at ambient pressure of 660 Torr (8.8 kPa) with electric fields of 10 to 35 kV cm(-1) (E/N of 52 to 180 Td) between two 1 mm wide metal strips, located on each analyzer plate between the first and second mobility stages. Field induced fragmentation (FIF) spectra were produced by characterizing, in a last stage, the mobilities of fragment ions from protonated monomers of 43 oxygen-containing volatile organic compounds from five chemical classes. The extent of fragmentation was proportional to E/N with alcohols, aldehydes, and ethers undergoing multiples steps of fragmentation; acetates fragmented only to a single ion, protonated acetic acid. In contrast, fragmentation of ketones occurred only for methyl i-butyl ketone and 2-hexanone. Fragment ion identities were supported by mass-analysis and known fragmentation routes and suggested that field induced fragmentation at ambient pressure can introduce structural information into FIF spectra, establishing a foundation for chemical identification using mobility methods" |
| Notes: | "PubMed-not-MEDLINEFowler, P E Pilgrim, J Z Lee, G Eiceman, G A eng England 2020/06/20 Analyst. 2020 Aug 7; 145(15):5314-5324. doi: 10.1039/d0an00665c. Epub 2020 Jun 19" |
